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Int. J. Mol. Sci. 2014, 15(2), 3234-3252; doi:10.3390/ijms15023234
Review

The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway

1
, 2
, 1
, 3,* , 2
 and 3,*
Received: 28 November 2013; in revised form: 8 February 2014 / Accepted: 10 February 2014 / Published: 21 February 2014
(This article belongs to the Special Issue Pathology and Treatment of Central Nervous System Diseases)
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Abstract: Recent studies have been conducted to examine the neuroprotective effects of acupuncture in many neurological disorders. Although the neuroprotective effects of acupuncture has been linked to changes in signaling pathways, accumulating evidence suggest the participation of endogenous biological mediators, such as the neurotrophin (NT) family of proteins, specifically, the brain derived neurotrophic factor (BDNF). Accordingly, acupuncture can inhibit neurodegeneration via expression and activation of BDNF. Moreover, recent studies have reported that acupuncture can increase ATP levels at local stimulated points. We have also demonstrated that acupuncture could activate monocytes and increase the expression of BDNF via the stimulation of ATP. The purpose of this article is to review the recent findings and ongoing studies on the neuroprotective roles of acupuncture and therapeutic implications of acupuncture-induced activation of BDNF and its signaling pathway.
Keywords: acupuncture; brain derived neurotrophic factor; neuroprotective; cyclophilin A acupuncture; brain derived neurotrophic factor; neuroprotective; cyclophilin A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lin, D.; De La Pena, I.; Lin, L.; Zhou, S.-F.; Borlongan, C.V.; Cao, C. The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway. Int. J. Mol. Sci. 2014, 15, 3234-3252.

AMA Style

Lin D, De La Pena I, Lin L, Zhou S-F, Borlongan CV, Cao C. The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway. International Journal of Molecular Sciences. 2014; 15(2):3234-3252.

Chicago/Turabian Style

Lin, Dong; De La Pena, Ike; Lin, Lili; Zhou, Shu-Feng; Borlongan, Cesar V.; Cao, Chuanhai. 2014. "The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway." Int. J. Mol. Sci. 15, no. 2: 3234-3252.



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