Associations between Variants in IL-33/ST2 Signaling Pathway Genes and Coronary Heart Disease Risk
AbstractThe IL-33/ST2 signaling pathway plays an important role in coronary artery disease (CHD); however, few studies have explored how variants in IL-33/ST2 genes influence CHD risk. Here, we examined the association between genetic variants in IL-33, ST2, and IL-1RAcP of the IL-33/ST2 axis and the risk of CHD. We conducted a case-controlled study with 1146 CHD cases and 1146 age- and sex-frequency-matched controls. Twenty-eight single nucleotide polymorphisms (SNPs) in IL-33, ST2, and IL-1RAcP were genotyped by Sequenom MassArray and TaqMan assay. Logistic regression was used to analyze these associations. The SNP rs4624606 in IL-1RAcP was nominally associated with CHD risk. The AA genotype was associated with a 1.85-fold increased risk of CHD (95% confidence interval (CI) = 1.01–3.36; p = 0.045) compared to the TT genotype. Further analysis showed that AA carriers also had a higher risk of CHD than TT + TA carriers (odds ratio (OR) = 1.85; 95% CI = 1.85–3.35; p = 0.043). However, no significant association was observed between variants in IL-33/ST2 genes and CHD risk. Further studies are needed to replicate our results in other ethnic groups with larger sample size. View Full-Text
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Wu, F.; He, M.; Wen, Q.; Zhang, W.; Yang, J.; Zhang, X.; Wu, T.; Cheng, L. Associations between Variants in IL-33/ST2 Signaling Pathway Genes and Coronary Heart Disease Risk. Int. J. Mol. Sci. 2014, 15, 23227-23239.
Wu F, He M, Wen Q, Zhang W, Yang J, Zhang X, Wu T, Cheng L. Associations between Variants in IL-33/ST2 Signaling Pathway Genes and Coronary Heart Disease Risk. International Journal of Molecular Sciences. 2014; 15(12):23227-23239.Chicago/Turabian Style
Wu, Fangqin; He, Mei'an; Wen, Qiang; Zhang, Wencai; Yang, Jinhua; Zhang, Xiaomin; Wu, Tangchun; Cheng, Longxian. 2014. "Associations between Variants in IL-33/ST2 Signaling Pathway Genes and Coronary Heart Disease Risk." Int. J. Mol. Sci. 15, no. 12: 23227-23239.