Next Article in Journal
The eTOX Data-Sharing Project to Advance in Silico Drug-Induced Toxicity Prediction
Next Article in Special Issue
The Cyclic Antibacterial Peptide Enterocin AS-48: Isolation, Mode of Action, and Possible Food Applications
Previous Article in Journal
Growth Suppression of Colorectal Cancer by Plant-Derived Multiple mAb CO17-1A × BR55 via Inhibition of ERK1/2 Phosphorylation
Previous Article in Special Issue
Peptide Array on Cellulose Support—A Screening Tool to Identify Peptides with Dipeptidyl-Peptidase IV Inhibitory Activity within the Sequence of α-Lactalbumin
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(11), 21120-21135; doi:10.3390/ijms151121120

Bioactive Peptides in Cereals and Legumes: Agronomical, Biochemical and Clinical Aspects

1
Department for Life Quality Studies, Alma Mater Studiorum University of Bologna, Corso D'Augusto 237, 47921 Rimini, Italy
2
Department of Agricultural Sciences, Alma Mater Studiorum University of Bologna, Viale Fanin 44, 40127 Bologna, Italy
3
Department of Medicine and Surgery, Alma Mater Studiorum University of Bologna, Via Albertoni 15, 40138 Bologna, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 September 2014 / Revised: 5 November 2014 / Accepted: 6 November 2014 / Published: 14 November 2014
(This article belongs to the Special Issue Bioactive Proteins and Peptides Derived from Food)
View Full-Text   |   Download PDF [693 KB, uploaded 14 November 2014]

Abstract

Cereals and legumes are key components of a healthy and balanced diet. Accordingly, many national nutritional guidelines emphasize their health promoting properties by placing them at the base of nutritional food pyramids. This concept is further validated by the observed correlation between a lower risk and occurrence of chronic diseases and the adherence to dietary patterns, like the Mediterranean diet, in which cereal grains, legumes and derived products represent a staple food. In the search for a dietary approach to control/prevent chronic degenerative diseases, protein derived bioactive peptides may represent one such source of health-enhancing components. These peptides may already be present in foods as natural components or may derive from hydrolysis by chemical or enzymatic treatments (digestion, hydrolysis or fermentation). Many reports are present in the literature regarding the bioactivity of peptides in vitro and a wide range of activities has been described, including antimicrobial properties, blood pressure-lowering (ACE inhibitory) effects, cholesterol-lowering ability, antithrombotic and antioxidant activities, enhancement of mineral absorption/bioavailability, cyto- or immunomodulatory effects, and opioid-like activities. However it is difficult to translate these observed effects to human. In fact, the active peptide may be degraded during digestion, or may not be absorbed or reach the target tissues at a concentration necessary to exert its function. This review will focus on bioactive peptides identified in cereals and legumes, from an agronomical and biochemical point of view, including considerations about requirements for the design of appropriate clinical trials necessary for the assessment of their nutraceutical effect in vivo. View Full-Text
Keywords: bioactive peptides; cereals; legumes; agronomical aspects; biological activities; clinical aspects bioactive peptides; cereals; legumes; agronomical aspects; biological activities; clinical aspects
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Malaguti, M.; Dinelli, G.; Leoncini, E.; Bregola, V.; Bosi, S.; Cicero, A.F.G.; Hrelia, S. Bioactive Peptides in Cereals and Legumes: Agronomical, Biochemical and Clinical Aspects. Int. J. Mol. Sci. 2014, 15, 21120-21135.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top