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Int. J. Mol. Sci. 2014, 15(11), 20948-20967; doi:10.3390/ijms151120948

Stem Cells: The Pursuit of Genomic Stability

1
Center for Regenerative Medicine, Mayo Clinic, Rochester, MN 55901, USA
2
Center for Clinical and Translational Sciences, Mayo Clinic, Rochester, MN 55901, USA
3
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55901, USA
4
Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55901, USA
*
Author to whom correspondence should be addressed.
Received: 2 October 2014 / Revised: 2 November 2014 / Accepted: 4 November 2014 / Published: 14 November 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Stem cells harbor significant potential for regenerative medicine as well as basic and clinical translational research. Prior to harnessing their reparative nature for degenerative diseases, concerns regarding their genetic integrity and mutation acquisition need to be addressed. Here we review pluripotent and multipotent stem cell response to DNA damage including differences in DNA repair kinetics, specific repair pathways (homologous recombination vs. non-homologous end joining), and apoptotic sensitivity. We also describe DNA damage and repair strategies during reprogramming and discuss potential genotoxic agents that can reduce the inherent risk for teratoma formation and mutation accumulation. Ensuring genomic stability in stem cell lines is required to achieve the quality control standards for safe clinical application. View Full-Text
Keywords: pluripotent stem cells; multipotent stem cells; DNA damage response; reprogramming efficiency; apoptotic susceptibility pluripotent stem cells; multipotent stem cells; DNA damage response; reprogramming efficiency; apoptotic susceptibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wyles, S.P.; Brandt, E.B.; Nelson, T.J. Stem Cells: The Pursuit of Genomic Stability. Int. J. Mol. Sci. 2014, 15, 20948-20967.

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