Hyperhomocysteinemia Accelerates Collagen Accumulation in the Adventitia of Balloon-Injured Rat Carotid Arteries via Angiotensin II Type 1 Receptor
Abstract
:1. Introduction
2. Results and Discussion
2.1. Serum Total Hcy
2.2. Effect of HHcy on Neointima Formation and Adventitial Hyperplasia
2.3. Effect of HHcy on Adventitial Expression of Collagen Type 1 and AT1R in Balloon-Injured Arteries
2.4. Effect of l-Hcy on Collagen Type 1 and AT1R Expression in Cultured Adventitial Fibroblasts
2.5. Discussion
3. Experimental Section
3.1. Animals and Treatments
3.2. Measurement of Serum Homocysteine Level
3.3. Balloon Injury of Rat Carotid Artery
3.4. Histology and Morphometry
3.5. Immunohistochemistry
3.6. Cell Culture of Vascular Fibroblasts
3.7. Western Blot
3.8. Statistical Analysis
4. Conclusions
Author Contributions
Conflicts of Interest
References
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Yao, D.; Sun, N.-L. Hyperhomocysteinemia Accelerates Collagen Accumulation in the Adventitia of Balloon-Injured Rat Carotid Arteries via Angiotensin II Type 1 Receptor. Int. J. Mol. Sci. 2014, 15, 19487-19498. https://doi.org/10.3390/ijms151119487
Yao D, Sun N-L. Hyperhomocysteinemia Accelerates Collagen Accumulation in the Adventitia of Balloon-Injured Rat Carotid Arteries via Angiotensin II Type 1 Receptor. International Journal of Molecular Sciences. 2014; 15(11):19487-19498. https://doi.org/10.3390/ijms151119487
Chicago/Turabian StyleYao, Dan, and Ning-Ling Sun. 2014. "Hyperhomocysteinemia Accelerates Collagen Accumulation in the Adventitia of Balloon-Injured Rat Carotid Arteries via Angiotensin II Type 1 Receptor" International Journal of Molecular Sciences 15, no. 11: 19487-19498. https://doi.org/10.3390/ijms151119487