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Int. J. Mol. Sci. 2014, 15(10), 18281-18309; doi:10.3390/ijms151018281

Dielectrophoresis for Bioparticle Manipulation

Robotics and Microsystems Center, College of Mechanical and Electrical Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215000, China
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Received: 24 June 2014 / Revised: 18 September 2014 / Accepted: 24 September 2014 / Published: 10 October 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

As an ideal method to manipulate biological particles, the dielectrophoresis (DEP) technique has been widely used in clinical diagnosis, disease treatment, drug development, immunoassays, cell sorting, etc. This review summarizes the research in the field of bioparticle manipulation based on DEP techniques. Firstly, the basic principle of DEP and its classical theories are introduced in brief; Secondly, a detailed introduction on the DEP technique used for bioparticle manipulation is presented, in which the applications are classified into five fields: capturing bioparticles to specific regions, focusing bioparticles in the sample, characterizing biomolecular interaction and detecting microorganism, pairing cells for electrofusion and separating different kinds of bioparticles; Thirdly, the effect of DEP on bioparticle viability is analyzed; Finally, the DEP techniques are summarized and future trends in bioparticle manipulation are suggested. View Full-Text
Keywords: dielectrophoresis; lab-on-a-chip; bioparticle; trapping; detection; focusing; pairing; separation dielectrophoresis; lab-on-a-chip; bioparticle; trapping; detection; focusing; pairing; separation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Qian, C.; Huang, H.; Chen, L.; Li, X.; Ge, Z.; Chen, T.; Yang, Z.; Sun, L. Dielectrophoresis for Bioparticle Manipulation. Int. J. Mol. Sci. 2014, 15, 18281-18309.

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