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Int. J. Mol. Sci. 2014, 15(10), 18175-18196; doi:10.3390/ijms151018175

Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas

Department of Neurosurgery, University RWTH Aachen, 52074 Aachen, Germany
Department of Anesthesiology, University RWTH Aachen, 52074 Aachen, Germany
Members are listed in Appendix.
Author to whom correspondence should be addressed.
Received: 14 August 2014 / Revised: 12 September 2014 / Accepted: 23 September 2014 / Published: 10 October 2014
(This article belongs to the Special Issue Neuroprotective Strategies 2014)
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Argon belongs to the group of noble gases, which are regarded as chemically inert. Astonishingly some of these gases exert biological properties and during the last decades more and more reports demonstrated neuroprotective and organoprotective effects. Recent studies predominately use in vivo or in vitro models for ischemic pathologies to investigate the effect of argon treatment. Promising data has been published concerning pathologies like cerebral ischemia, traumatic brain injury and hypoxic ischemic encephalopathy. However, models applied and administration of the therapeutic gas vary. Here we provide a systematic review to summarize the available data on argon’s neuro- and organoprotective effects and discuss its possible mechanism of action. We aim to provide a summary to allow further studies with a more homogeneous setting to investigate possible clinical applications of argon. View Full-Text
Keywords: argon; neuroprotection; organoprotection; inert gas; hypoxia; ischemia; cytoprotection argon; neuroprotection; organoprotection; inert gas; hypoxia; ischemia; cytoprotection

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Höllig, A.; Schug, A.; Fahlenkamp, A.V.; Rossaint, R.; Coburn, M.; Argon Organo-Protective Network (AON). Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas. Int. J. Mol. Sci. 2014, 15, 18175-18196.

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