Next Article in Journal
Intermittently Administered Parathyroid Hormone [1–34] Promotes Tendon-Bone Healing in a Rat Model
Previous Article in Journal
Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(10), 17344-17365; doi:10.3390/ijms151017344

Gender-Associated Genomic Differences in Colorectal Cancer: Clinical Insight from Feminization of Male Cancer Cells

1
Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait
2
Kuwait Medical Genetics Center, Ministry of Health, Safat 13001, Kuwait
3
Department of Pharmacology, Faculty of Medicine, Health Sciences Center, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait
4
Department of Forensic Evidence, Ministry of Interior, P.O. Box 12500, Shamiya 71655, Kuwait
*
Author to whom correspondence should be addressed.
Received: 27 May 2014 / Revised: 15 September 2014 / Accepted: 17 September 2014 / Published: 29 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [4050 KB, uploaded 29 September 2014]   |  

Abstract

Gender-related differences in colorectal cancer (CRC) are not fully understood. Recent studies have shown that CRC arising in females are significantly associated with CpG island methylator phenotype (CIMP-high). Using array comparative genomic hybridization, we analyzed a cohort of 116 CRCs (57 males, 59 females) for chromosomal copy number aberrations (CNA) and found that CRC in females had significantly higher numbers of gains involving chromosome arms 1q21.2–q21.3, 4q13.2, 6p21.1 and 16p11.2 and copy number losses of chromosome arm 11q25 compared to males. Interestingly, a subset of male CRCs (46%) exhibited a "feminization" phenomenon in the form of gains of X chromosomes (or an arm of X) and/or losses of the Y chromosome. Feminization of cancer cells was significantly associated with microsatellite-stable CRCs (p-value 0.003) and wild-type BRAF gene status (p-value 0.009). No significant association with other clinicopathological parameters was identified including disease-free survival. In summary, our data show that some CNAs in CRC may be gender specific and that male cancers characterized by feminization may constitute a specific subset of CRCs that warrants further investigation. View Full-Text
Keywords: X chromosome; comparative genomic hybridization; colorectal cancer; copy number aberration; gender X chromosome; comparative genomic hybridization; colorectal cancer; copy number aberration; gender
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ali, R.H.; Marafie, M.J.; Bitar, M.S.; Al-Dousari, F.; Ismael, S.; Haider, H.B.; Al-Ali, W.; Jacob, S.P.; Al-Mulla, F. Gender-Associated Genomic Differences in Colorectal Cancer: Clinical Insight from Feminization of Male Cancer Cells. Int. J. Mol. Sci. 2014, 15, 17344-17365.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top