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Int. J. Mol. Sci. 2014, 15(1), 712-724; doi:10.3390/ijms15010712
Article

Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer

1
, 2
, 2
, 1
 and 2,3,*
Received: 5 December 2013; in revised form: 23 December 2013 / Accepted: 25 December 2013 / Published: 7 January 2014
(This article belongs to the collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Abstract: The CYP19 gene encodes aromatase, an enzyme catalyzing the conversion of androgens to estrogens. Studies analyzing associations between single nucleotide polymorphisms in CYP19 and breast cancer risk have shown inconsistent results. The rs10046 polymorphism is located in the 3' untranslated region of the CYP19 gene, but the influence of this polymorphism on breast cancer risk is unclear. In this study, we investigated the impact of rs10046 SNP on breast cancer risk, age at onset and association with clinical characteristics in an Austrian population of 274 breast cancer patients and 253 controls. The results show that a significantly increased fraction of patients with the TT genotype of rs10046 develop breast cancer under the age of 50 (41.8% of TT patients, compared to 26.6% of C carriers; p = 0.018, Chi-square test). No rs10046 genotypes were significantly associated with increased breast cancer risk or patient characteristics other than age at onset. These results suggest that the rs10046 polymorphism in the CYP19 gene may have an effect on breast cancer susceptibility at an age under 50 in the investigated population.
Keywords: breast cancer; CYP19/aromatase; rs10046; rs2236722; SNP breast cancer; CYP19/aromatase; rs10046; rs2236722; SNP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zins, K.; Mogg, M.; Schneeberger, C.; Abraham, D.; Schreiber, M. Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer. Int. J. Mol. Sci. 2014, 15, 712-724.

AMA Style

Zins K, Mogg M, Schneeberger C, Abraham D, Schreiber M. Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer. International Journal of Molecular Sciences. 2014; 15(1):712-724.

Chicago/Turabian Style

Zins, Karin; Mogg, Maurice; Schneeberger, Christian; Abraham, Dietmar; Schreiber, Martin. 2014. "Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer." Int. J. Mol. Sci. 15, no. 1: 712-724.


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