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Int. J. Mol. Sci. 2014, 15(1), 456-467; doi:10.3390/ijms15010456
Article

Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats

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Received: 12 November 2013; in revised form: 26 December 2013 / Accepted: 26 December 2013 / Published: 2 January 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: In the present study, post inflammation irritable bowel syndrome (PI-IBS) rats were firstly established by intracolonic instillation of acetic acid with restraint stress. Then the pharmacokinetics of berberine in the rat plasma were compared after oral administration of berberine hydrochloride (25 mg/kg) to normal rats and PI-IBS rats. Quantification of berberine in the rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method. Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software. Compared with the normal group, area under the plasma concentration vs. time curve from zero to last sampling time (AUC0–t) and total body clearance (CL/F) in the model group significantly increased or decreased, (2039.49 ± 492.24 vs. 2763.43 ± 203.14; 4999.34 ± 1198.79 vs. 3270.57 ± 58.32) respectively. The results indicated that the pharmacokinetic process of berberine could be altered in PI-IBS pathological conditions.
Keywords: berberine; pharmacokinetic; absorption; irritable bowel syndrome berberine; pharmacokinetic; absorption; irritable bowel syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gong, Z.; Chen, Y.; Zhang, R.; Wang, Y.; Guo, Y.; Yang, Q.; Zhang, H.; Dong, Y.; Weng, X.; Gao, S.; Zhu, X. Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats. Int. J. Mol. Sci. 2014, 15, 456-467.

AMA Style

Gong Z, Chen Y, Zhang R, Wang Y, Guo Y, Yang Q, Zhang H, Dong Y, Weng X, Gao S, Zhu X. Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats. International Journal of Molecular Sciences. 2014; 15(1):456-467.

Chicago/Turabian Style

Gong, Zipeng; Chen, Ying; Zhang, Ruijie; Wang, Yinghan; Guo, Yan; Yang, Qing; Zhang, Haixian; Dong, Yu; Weng, Xiaogang; Gao, Shuangrong; Zhu, Xiaoxin. 2014. "Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats." Int. J. Mol. Sci. 15, no. 1: 456-467.


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