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Int. J. Mol. Sci. 2014, 15(1), 1358-1373; doi:10.3390/ijms15011358

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

Received: 10 December 2013 / Revised: 2 January 2014 / Accepted: 7 January 2014 / Published: 20 January 2014
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Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including virtual screening and structure-based drug design. These computational methods are relatively fast and cheap, and are proving to be of great benefit for the rational development of more potent aaRS inhibitors and other pharmaceutical agents that may usher in a much needed generation of new antibiotics.
Keywords: aminoacyl-tRNA synthetase; inhibitor; antibiotics; virtual screening; structure-based drug design; docking aminoacyl-tRNA synthetase; inhibitor; antibiotics; virtual screening; structure-based drug design; docking
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhao, Y.; Meng, Q.; Bai, L.; Zhou, H. In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors. Int. J. Mol. Sci. 2014, 15, 1358-1373.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert