Int. J. Mol. Sci. 2014, 15(1), 1358-1373; doi:10.3390/ijms15011358

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

1,2email, 1email, 2email and 1,2,* email
Received: 10 December 2013; in revised form: 2 January 2014 / Accepted: 7 January 2014 / Published: 20 January 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including virtual screening and structure-based drug design. These computational methods are relatively fast and cheap, and are proving to be of great benefit for the rational development of more potent aaRS inhibitors and other pharmaceutical agents that may usher in a much needed generation of new antibiotics.
Keywords: aminoacyl-tRNA synthetase; inhibitor; antibiotics; virtual screening; structure-based drug design; docking
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MDPI and ACS Style

Zhao, Y.; Meng, Q.; Bai, L.; Zhou, H. In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors. Int. J. Mol. Sci. 2014, 15, 1358-1373.

AMA Style

Zhao Y, Meng Q, Bai L, Zhou H. In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors. International Journal of Molecular Sciences. 2014; 15(1):1358-1373.

Chicago/Turabian Style

Zhao, Yaxue; Meng, Qingqing; Bai, Linquan; Zhou, Huchen. 2014. "In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors." Int. J. Mol. Sci. 15, no. 1: 1358-1373.

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