Open AccessThis article is
- freely available
In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
* Author to whom correspondence should be addressed.
Received: 10 December 2013; in revised form: 2 January 2014 / Accepted: 7 January 2014 / Published: 20 January 2014
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including virtual screening and structure-based drug design. These computational methods are relatively fast and cheap, and are proving to be of great benefit for the rational development of more potent aaRS inhibitors and other pharmaceutical agents that may usher in a much needed generation of new antibiotics.
Keywords: aminoacyl-tRNA synthetase; inhibitor; antibiotics; virtual screening; structure-based drug design; docking
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Zhao, Y.; Meng, Q.; Bai, L.; Zhou, H. In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors. Int. J. Mol. Sci. 2014, 15, 1358-1373.
Zhao Y, Meng Q, Bai L, Zhou H. In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors. International Journal of Molecular Sciences. 2014; 15(1):1358-1373.
Zhao, Yaxue; Meng, Qingqing; Bai, Linquan; Zhou, Huchen. 2014. "In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors." Int. J. Mol. Sci. 15, no. 1: 1358-1373.