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Molecular Basis of Cardiac Myxomas
Department of Pathology, Toronto General Hospital, University Health Network, Toronto, ON M5G2C4, Canada
Division of Cardiology, Department of Medicine, University of Toronto, Toronto, ON M5G2C4, Canada
Division of Experimental Therapeutics, Cardiovascular Toronto General Research Institute, Toronto General Hospital, Toronto, ON M5G2C4, Canada
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 12 December 2013; in revised form: 4 January 2014 / Accepted: 8 January 2014 / Published: 20 January 2014
Abstract: Cardiac tumors are rare, and of these, primary cardiac tumors are even rarer. Metastatic cardiac tumors are about 100 times more common than the primary tumors. About 90% of primary cardiac tumors are benign, and of these the most common are cardiac myxomas. Approximately 12% of primary cardiac tumors are completely asymptomatic while others present with one or more signs and symptoms of the classical triad of hemodynamic changes due to intracardiac obstruction, embolism and nonspecific constitutional symptoms. Echocardiography is highly sensitive and specific in detecting cardiac tumors. Other helpful investigations are chest X-rays, magnetic resonance imaging and computerized tomography scan. Surgical excision is the treatment of choice for primary cardiac tumors and is usually associated with a good prognosis. This review article will focus on the general features of benign cardiac tumors with an emphasis on cardiac myxomas and their molecular basis.
Keywords: primary cardiac tumors; cardiac myxomas; molecular genetics; Carney complex
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Singhal, P.; Luk, A.; Rao, V.; Butany, J. Molecular Basis of Cardiac Myxomas. Int. J. Mol. Sci. 2014, 15, 1315-1337.
Singhal P, Luk A, Rao V, Butany J. Molecular Basis of Cardiac Myxomas. International Journal of Molecular Sciences. 2014; 15(1):1315-1337.
Singhal, Pooja; Luk, Adriana; Rao, Vivek; Butany, Jagdish. 2014. "Molecular Basis of Cardiac Myxomas." Int. J. Mol. Sci. 15, no. 1: 1315-1337.