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A Polymorphism at the 3'-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma
Department of Internal Medicine, The Affiliated Tumor Hospital, Harbin Medical University, Haping Road 150 of Nangang District, Harbin 150081, Heilongjiang, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 9 August 2013; in revised form: 26 August 2013 / Accepted: 5 September 2013 / Published: 13 September 2013
Abstract: Estrogen-related genes and the fat mass and obesity-associated (FTO) gene play a critical role in estrogen metabolism, and those polymorphisms are associated with a poor prognosis in breast cancer. However, little is known about the association between these polymorphisms and the efficacy of anastrozole. The aim was to investigate the impact of the genetic polymorphisms, CYP19A1, 17-β-HSD-1 and FTO, on the response to anastrozole in metastatic breast carcinoma (MBC) and to evaluate the impact of those polymorphisms on various clinicopathologic features. Two-hundred seventy-two women with hormone receptor-positive MBC treated with anastrozole were identified retrospectively. DNA was extracted from peripheral blood and genotyped for five variants in three candidate genes. Time to progression was improved in patients carrying the variant alleles of rs4646 when compared to patients with the wild-type allele (16.40 months versus 13.52 months; p = 0.049). The rs4646 variant alleles were significantly associated with longer overall survival (37.3 months versus 31.6 months; p = 0.007). This relationship was not observed with the rs10046, rs2830, rs9926298 and rs9939609 polymorphisms. The findings of this study indicate that rs4646 polymorphism in the CYP19A1 gene may serve as a prognostic maker of the response to anastrozole in patients with MBC who are treated with anastrozole.
Keywords: metastatic breast carcinoma; aromatase gene; anastrozole; prognosis; polymorphism
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Liu, L.; Bai, Y.-X.; Zhou, J.-H.; Sun, X.-W.; Sui, H.; Zhang, W.-J.; Yuan, H.-H.; Xie, R.; Wei, X.-L.; Zhang, T.-T.; Huang, P.; Li, Y.-J.; Wang, J.-X.; Zhao, S.; Zhang, Q.-Y. A Polymorphism at the 3'-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma. Int. J. Mol. Sci. 2013, 14, 18973-18988.
Liu L, Bai Y-X, Zhou J-H, Sun X-W, Sui H, Zhang W-J, Yuan H-H, Xie R, Wei X-L, Zhang T-T, Huang P, Li Y-J, Wang J-X, Zhao S, Zhang Q-Y. A Polymorphism at the 3'-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma. International Journal of Molecular Sciences. 2013; 14(9):18973-18988.
Liu, Lei; Bai, Yu-Xian; Zhou, Jian-Hua; Sun, Xiu-Wei; Sui, Hong; Zhang, Wen-Jie; Yuan, Heng-Heng; Xie, Rui; Wei, Xiao-Li; Zhang, Ting-Ting; Huang, Peng; Li, Yan-Jing; Wang, Jing-Xuan; Zhao, Shu; Zhang, Qing-Yuan. 2013. "A Polymorphism at the 3'-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma." Int. J. Mol. Sci. 14, no. 9: 18973-18988.