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Int. J. Mol. Sci. 2013, 14(9), 18850-18860; doi:10.3390/ijms140918850
Article

A Facile and Efficient Synthesis of Diaryl Amines or Ethers under Microwave Irradiation at Presence of KF/Al2O3 without Solvent and Their Anti-Fungal Biological Activities against Six Phytopathogens

1,†
, 1,†
, 1
, 1
, 1
 and 1,2,*
1 College of Science, Northwest A & F University, Yangling 712100, China 2 Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 20032, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 8 July 2013 / Revised: 5 September 2013 / Accepted: 6 September 2013 / Published: 12 September 2013

Abstract

A series of diaryl amines, ethers and thioethers were synthesized under microwave irradiation efficiently at presence of KF/Al2O3 in 83%–96% yields without any solvent. The salient characters of this method lie in short reaction time, high yields, general applicability to substrates and simple workup procedure. At the same time, their antifungal biological activities against six phytopathogen were evaluated. Most of the compounds (3b, 3c, 3go) are more potent than thiophannate-methyl against to Magnaporthe oryzae. This implies that diaryl amine or ether moiety may be helpful in finding a fungicide against Magnaporthe oryzae.
Keywords: microwave-assisted organic synthesis; diaryl amine; diaryl ether; KF/Al2O3 microwave-assisted organic synthesis; diaryl amine; diaryl ether; KF/Al2O3
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, L.-Z.; Han, P.; Li, Y.-Q.; Xu, Y.-M.; Zhang, T.; Du, Z.-T. A Facile and Efficient Synthesis of Diaryl Amines or Ethers under Microwave Irradiation at Presence of KF/Al2O3 without Solvent and Their Anti-Fungal Biological Activities against Six Phytopathogens. Int. J. Mol. Sci. 2013, 14, 18850-18860.

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