Int. J. Mol. Sci. 2013, 14(9), 18758-18789; doi:10.3390/ijms140918758
Review

Peptide-Lipid Interactions: Experiments and Applications

1,2,* email, 1email, 1email, 3email, 1,2email and 3,* email
Received: 18 June 2013; in revised form: 27 August 2013 / Accepted: 28 August 2013 / Published: 12 September 2013
(This article belongs to the Special Issue Computational Modelling of Biological Membranes)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of modern biotechnology is obtaining new potent pharmaceutical agents whose biological action is dependent on the binding of peptides to lipid-bilayers. Several issues need to be addressed such as secondary structure, orientation, oligomerization and localization inside the membrane. At the same time, the structural effects which the peptides cause on the lipid bilayer are important for the interactions and need to be elucidated. The structural characterization of membrane active peptides in membranes is a harsh experimental challenge. It is in fact accepted that no single experimental technique can give a complete structural picture of the interaction, but rather a combination of different techniques is necessary.
Keywords: peptide; membrane; bacteria; virus
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MDPI and ACS Style

Galdiero, S.; Falanga, A.; Cantisani, M.; Vitiello, M.; Morelli, G.; Galdiero, M. Peptide-Lipid Interactions: Experiments and Applications. Int. J. Mol. Sci. 2013, 14, 18758-18789.

AMA Style

Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M. Peptide-Lipid Interactions: Experiments and Applications. International Journal of Molecular Sciences. 2013; 14(9):18758-18789.

Chicago/Turabian Style

Galdiero, Stefania; Falanga, Annarita; Cantisani, Marco; Vitiello, Mariateresa; Morelli, Giancarlo; Galdiero, Massimiliano. 2013. "Peptide-Lipid Interactions: Experiments and Applications." Int. J. Mol. Sci. 14, no. 9: 18758-18789.

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