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Int. J. Mol. Sci. 2013, 14(9), 18758-18789; doi:10.3390/ijms140918758

Peptide-Lipid Interactions: Experiments and Applications

1,2,* , 1
1 Department of Pharmacy, CIRPEB and DFM—University of Naples "Federico II", Via Mezzocannone 16, 80134 Napoli, Italy 2 Institute of Biostructures and Bioimages—CNR, Via Mezzocannone 16, 80134 Napoli, Italy 3 Department of Experimental Medicine—Second University of Naples, Via De Crecchio 7, 80138 Napoli, Italy
* Authors to whom correspondence should be addressed.
Received: 18 June 2013 / Revised: 27 August 2013 / Accepted: 28 August 2013 / Published: 12 September 2013
(This article belongs to the Special Issue Computational Modelling of Biological Membranes)
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The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of modern biotechnology is obtaining new potent pharmaceutical agents whose biological action is dependent on the binding of peptides to lipid-bilayers. Several issues need to be addressed such as secondary structure, orientation, oligomerization and localization inside the membrane. At the same time, the structural effects which the peptides cause on the lipid bilayer are important for the interactions and need to be elucidated. The structural characterization of membrane active peptides in membranes is a harsh experimental challenge. It is in fact accepted that no single experimental technique can give a complete structural picture of the interaction, but rather a combination of different techniques is necessary.
Keywords: peptide; membrane; bacteria; virus peptide; membrane; bacteria; virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Galdiero, S.; Falanga, A.; Cantisani, M.; Vitiello, M.; Morelli, G.; Galdiero, M. Peptide-Lipid Interactions: Experiments and Applications. Int. J. Mol. Sci. 2013, 14, 18758-18789.

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