Int. J. Mol. Sci. 2013, 14(9), 17972-17985; doi:10.3390/ijms140917972
Review

Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer

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Received: 2 August 2013; in revised form: 19 August 2013 / Accepted: 23 August 2013 / Published: 3 September 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. Although conclusive evidence is still lacking, epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has chemopreventive properties against CRC. Similarly, regular consumption of mesalazine, a drug structurally related to NSAIDs, seems to reduce the risk of CRC in patients with ulcerative colitis. These observations are supported by a large body of experimental data showing the ability of such drugs to inhibit multiple pathways that sustain colon carcinogenesis. This review summarizes the current information on the molecular mechanisms by which NSAIDs and mesalazine could interfere with CRC cell growth and survival.
Keywords: aspirin; non-steroidal anti-inflammatory drugs; 5-aminosalicylic acid; cyclooxygenase; prostaglandins; colitis-associated colon cancer; carcinogenesis; Wnt/β-catenin; cell cycle; DNA replication fidelity
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MDPI and ACS Style

Stolfi, C.; De Simone, V.; Pallone, F.; Monteleone, G. Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer. Int. J. Mol. Sci. 2013, 14, 17972-17985.

AMA Style

Stolfi C, De Simone V, Pallone F, Monteleone G. Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer. International Journal of Molecular Sciences. 2013; 14(9):17972-17985.

Chicago/Turabian Style

Stolfi, Carmine; De Simone, Veronica; Pallone, Francesco; Monteleone, Giovanni. 2013. "Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer." Int. J. Mol. Sci. 14, no. 9: 17972-17985.

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