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Int. J. Mol. Sci. 2013, 14(8), 16851-16865; doi:10.3390/ijms140816851
Article

Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid

1,†
, 1,2,†
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 and 1,*
Received: 16 April 2013; in revised form: 30 June 2013 / Accepted: 7 July 2013 / Published: 15 August 2013
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Abstract: A series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and purine, at the C-1 position. The preliminary binding properties of these compounds to calf thymus DNA (CT-DNA) have been investigated by UV-absorption and fluorescence spectroscopy. The results indicated that all the target compounds can interact with CT-DNA, and the acridine derivative, 3b, showed the highest key selection vector (KSV) value, which suggested that compound 3b binds most strongly to CT-DNA.
Keywords: glycuronic acid; DNA bis-intercaltor; synthesis and design glycuronic acid; DNA bis-intercaltor; synthesis and design
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhao, J.; Li, W.; Ma, R.; Chen, S.; Ren, S.; Jiang, T. Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid. Int. J. Mol. Sci. 2013, 14, 16851-16865.

AMA Style

Zhao J, Li W, Ma R, Chen S, Ren S, Jiang T. Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid. International Journal of Molecular Sciences. 2013; 14(8):16851-16865.

Chicago/Turabian Style

Zhao, Jiuyang; Li, Wei; Ma, Rui; Chen, Shaopeng; Ren, Sumei; Jiang, Tao. 2013. "Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid." Int. J. Mol. Sci. 14, no. 8: 16851-16865.



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