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Int. J. Mol. Sci. 2013, 14(8), 16851-16865; doi:10.3390/ijms140816851

Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid

1,†
,
1,2,†
,
1,†
,
1
,
1
and
1,*
1
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao 266003, China
2
School of Pharmacy, Jining Medical University, Rizhao 276826, China
These authors contributed equally to this study.
*
Author to whom correspondence should be addressed.
Received: 16 April 2013 / Revised: 30 June 2013 / Accepted: 7 July 2013 / Published: 15 August 2013
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Abstract

A series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and purine, at the C-1 position. The preliminary binding properties of these compounds to calf thymus DNA (CT-DNA) have been investigated by UV-absorption and fluorescence spectroscopy. The results indicated that all the target compounds can interact with CT-DNA, and the acridine derivative, 3b, showed the highest key selection vector (KSV) value, which suggested that compound 3b binds most strongly to CT-DNA.
Keywords: glycuronic acid; DNA bis-intercaltor; synthesis and design glycuronic acid; DNA bis-intercaltor; synthesis and design
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MDPI and ACS Style

Zhao, J.; Li, W.; Ma, R.; Chen, S.; Ren, S.; Jiang, T. Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid. Int. J. Mol. Sci. 2013, 14, 16851-16865.

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