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Melatonin Signaling and Its Modulation of PfNF-YB Transcription Factor Expression in Plasmodium falciparum
Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508900, Brazil
Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
* Author to whom correspondence should be addressed.
Received: 19 May 2013; in revised form: 23 June 2013 / Accepted: 25 June 2013 / Published: 1 July 2013
Abstract: Malaria is one of the most severe tropical infectious diseases. More than 220 million people around the world have a clinical malaria infection and about one million die because of Plasmodium annually. This parasitic pathogen replicates efficiently in its human host making it difficult to eradicate. It is transmitted by mosquito vectors and so far mosquito control programs have not effectively eliminated this transmission. Because of malaria’s enormous health and economic impact and the need to develop new control and eventual elimination strategies, a big research effort has been made to better understand the biology of this parasite and its interactions with its vertebrate host. Determination of the genome sequence and organization, the elucidation of the role of key proteins, and cell signaling studies have helped to develop an understanding of the molecular mechanisms that provide the parasite’s versatility. The parasite can sense its environment and adapt to benefit its survival, indeed this is essential for it to complete its life cycle. For many years we have studied how the Plasmodium parasite is able to sense melatonin. In this review we discuss the melatonin signaling pathway and its role in the control of Plasmodium replication and development.
Keywords: melatonin; malaria; signaling modulation; Plasmodium
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Lima, W.R.; Holder, A.A.; Garcia, C.R.S. Melatonin Signaling and Its Modulation of PfNF-YB Transcription Factor Expression in Plasmodium falciparum. Int. J. Mol. Sci. 2013, 14, 13704-13718.
Lima WR, Holder AA, Garcia CRS. Melatonin Signaling and Its Modulation of PfNF-YB Transcription Factor Expression in Plasmodium falciparum. International Journal of Molecular Sciences. 2013; 14(7):13704-13718.
Lima, Wânia R.; Holder, Anthony A.; Garcia, Célia R.S. 2013. "Melatonin Signaling and Its Modulation of PfNF-YB Transcription Factor Expression in Plasmodium falciparum." Int. J. Mol. Sci. 14, no. 7: 13704-13718.