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Int. J. Mol. Sci. 2013, 14(7), 13447-13462; doi:10.3390/ijms140713447
Review

The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering

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Received: 15 May 2013; in revised form: 17 June 2013 / Accepted: 20 June 2013 / Published: 27 June 2013
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Abstract: Arginine-Glycine-Aspartic (RGD), is the specific recognition site of integrins with theirs ligands, and regulates cell-cell and cell-extracellular matrix interactions. The RGD motif can be combined with integrins overexpressed on the tumor neovasculature and tumor cells with a certain affinity, becoming the new target for imaging agents, and drugs, and gene delivery for tumor treatment. Further, RGD as a biomimetic peptide can also promote cell adherence to the matrix, prevent cell apoptosis and accelerate new tissue regeneration. Functionalizing material surfaces with RGD can improve cell/biomaterial interactions, which facilitates the generation of tissue-engineered constructs. This paper reviews the main functions and advantages of RGD, describes the applications of RGD in imaging agents, drugs, gene delivery for tumor therapy, and highlights the role of RGD in promoting the development of tissue engineering (bone regeneration, cornea repair, artificial neovascularization) in recent years.
Keywords: RGD; tumor therapy; tissue engineering RGD; tumor therapy; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, F.; Li, Y.; Shen, Y.; Wang, A.; Wang, S.; Xie, T. The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering. Int. J. Mol. Sci. 2013, 14, 13447-13462.

AMA Style

Wang F, Li Y, Shen Y, Wang A, Wang S, Xie T. The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering. International Journal of Molecular Sciences. 2013; 14(7):13447-13462.

Chicago/Turabian Style

Wang, Fen; Li, Yuanyuan; Shen, Yingqiang; Wang, Anming; Wang, Shuling; Xie, Tian. 2013. "The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering." Int. J. Mol. Sci. 14, no. 7: 13447-13462.



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