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The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering
College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China
Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou 311121, China
College of Biological and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China
* Authors to whom correspondence should be addressed.
Received: 15 May 2013; in revised form: 17 June 2013 / Accepted: 20 June 2013 / Published: 27 June 2013
Abstract: Arginine-Glycine-Aspartic (RGD), is the specific recognition site of integrins with theirs ligands, and regulates cell-cell and cell-extracellular matrix interactions. The RGD motif can be combined with integrins overexpressed on the tumor neovasculature and tumor cells with a certain affinity, becoming the new target for imaging agents, and drugs, and gene delivery for tumor treatment. Further, RGD as a biomimetic peptide can also promote cell adherence to the matrix, prevent cell apoptosis and accelerate new tissue regeneration. Functionalizing material surfaces with RGD can improve cell/biomaterial interactions, which facilitates the generation of tissue-engineered constructs. This paper reviews the main functions and advantages of RGD, describes the applications of RGD in imaging agents, drugs, gene delivery for tumor therapy, and highlights the role of RGD in promoting the development of tissue engineering (bone regeneration, cornea repair, artificial neovascularization) in recent years.
Keywords: RGD; tumor therapy; tissue engineering
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MDPI and ACS Style
Wang, F.; Li, Y.; Shen, Y.; Wang, A.; Wang, S.; Xie, T. The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering. Int. J. Mol. Sci. 2013, 14, 13447-13462.
Wang F, Li Y, Shen Y, Wang A, Wang S, Xie T. The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering. International Journal of Molecular Sciences. 2013; 14(7):13447-13462.
Wang, Fen; Li, Yuanyuan; Shen, Yingqiang; Wang, Anming; Wang, Shuling; Xie, Tian. 2013. "The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering." Int. J. Mol. Sci. 14, no. 7: 13447-13462.