Int. J. Mol. Sci. 2013, 14(7), 13463-13481; doi:10.3390/ijms140713463
Article

Non-Covalent Synthesis of Metal Oxide Nanoparticle–Heparin Hybrid Systems: A New Approach to Bioactive Nanoparticles

1,2,* email, 1email, 1email, 3email, 3email, 3email, 2,4email and 2,4email
Received: 1 March 2013; in revised form: 24 May 2013 / Accepted: 14 June 2013 / Published: 27 June 2013
(This article belongs to the Special Issue Bioactive Nanoparticles 2013)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Heparin has been conjugated to Fe3O4, Co3O4, and NiO nanoparticles (NPs) through electrostatic interactions, producing colloidal suspensions of hybrid metal oxide heparin NPs that are stable in water. Negative zeta potentials and retention of heparin’s ability to capture toluidine blue indicate that heparin’s negative charges are exposed on the surface of the coated NPs. IR results confirmed the formation of nanohybrids as did NMR experiments, which were also interpreted on the basis of toluidine blue tests. Transmission electron microscopy results revealed that the heparin coating does not modify the shape or dimension of the NPs. Dynamic light scattering and negative zeta potential measurements confirmed that heparin surface functionalisation is an effective strategy to prevent NP aggregation.
Keywords: heparin; transition metal oxide nanoparticles; organic inorganic nanostructures; electrostatic interaction; NMR spectroscopy; microscopy
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MDPI and ACS Style

Vismara, E.; Valerio, A.; Coletti, A.; Torri, G.; Bertini, S.; Eisele, G.; Gornati, R.; Bernardini, G. Non-Covalent Synthesis of Metal Oxide Nanoparticle–Heparin Hybrid Systems: A New Approach to Bioactive Nanoparticles. Int. J. Mol. Sci. 2013, 14, 13463-13481.

AMA Style

Vismara E, Valerio A, Coletti A, Torri G, Bertini S, Eisele G, Gornati R, Bernardini G. Non-Covalent Synthesis of Metal Oxide Nanoparticle–Heparin Hybrid Systems: A New Approach to Bioactive Nanoparticles. International Journal of Molecular Sciences. 2013; 14(7):13463-13481.

Chicago/Turabian Style

Vismara, Elena; Valerio, Antonio; Coletti, Alessia; Torri, Giangiacomo; Bertini, Sabrina; Eisele, Giorgio; Gornati, Rosalba; Bernardini, Giovanni. 2013. "Non-Covalent Synthesis of Metal Oxide Nanoparticle–Heparin Hybrid Systems: A New Approach to Bioactive Nanoparticles." Int. J. Mol. Sci. 14, no. 7: 13463-13481.


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