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New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium
Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Taitung District Agricultural Research and Extension Station, Taitung 950, Taiwan
* Author to whom correspondence should be addressed.
Received: 16 April 2013; in revised form: 3 June 2013 / Accepted: 8 June 2013 / Published: 25 June 2013
Abstract: Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5–17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3–6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.
Keywords: Hedychium coronarium; Zingiberaceae; labdane-type diterpenoid; anti-inflammatory activity
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Chen, J.-J.; Ting, C.-W.; Wu, Y.-C.; Hwang, T.-L.; Cheng, M.-J.; Sung, P.-J.; Wang, T.-C.; Chen, J.-F. New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium. Int. J. Mol. Sci. 2013, 14, 13063-13077.
Chen J-J, Ting C-W, Wu Y-C, Hwang T-L, Cheng M-J, Sung P-J, Wang T-C, Chen J-F. New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium. International Journal of Molecular Sciences. 2013; 14(7):13063-13077.
Chen, Jih-Jung; Ting, Chia-Wei; Wu, Yi-Chin; Hwang, Tsong-Long; Cheng, Ming-Jen; Sung, Ping-Jyun; Wang, Tai-Chi; Chen, Jinn-Fen. 2013. "New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium." Int. J. Mol. Sci. 14, no. 7: 13063-13077.