Int. J. Mol. Sci. 2013, 14(7), 13063-13077; doi:10.3390/ijms140713063
Article

New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium

1,* email, 2email, 1email, 3email, 4email, 5email, 1email and 6email
Received: 16 April 2013; in revised form: 3 June 2013 / Accepted: 8 June 2013 / Published: 25 June 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (517). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 36, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.
Keywords: Hedychium coronarium; Zingiberaceae; labdane-type diterpenoid; anti-inflammatory activity
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MDPI and ACS Style

Chen, J.-J.; Ting, C.-W.; Wu, Y.-C.; Hwang, T.-L.; Cheng, M.-J.; Sung, P.-J.; Wang, T.-C.; Chen, J.-F. New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium. Int. J. Mol. Sci. 2013, 14, 13063-13077.

AMA Style

Chen J-J, Ting C-W, Wu Y-C, Hwang T-L, Cheng M-J, Sung P-J, Wang T-C, Chen J-F. New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium. International Journal of Molecular Sciences. 2013; 14(7):13063-13077.

Chicago/Turabian Style

Chen, Jih-Jung; Ting, Chia-Wei; Wu, Yi-Chin; Hwang, Tsong-Long; Cheng, Ming-Jen; Sung, Ping-Jyun; Wang, Tai-Chi; Chen, Jinn-Fen. 2013. "New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium." Int. J. Mol. Sci. 14, no. 7: 13063-13077.


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