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Candidate Biomarkers for Genetic and Clinicopathological Diagnosis of Endometrial Cancer
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinanomachi 35 Shinjuku-ku, Tokyo 160-8582, Japan
* Author to whom correspondence should be addressed.
Received: 27 February 2013; in revised form: 15 May 2013 / Accepted: 20 May 2013 / Published: 6 June 2013
Abstract: The recent increase in the frequency of endometrial cancer has emphasized the need for accurate diagnosis and improved treatment. The current diagnosis is still based on conventional pathological indicators, such as clinical stage, tumor differentiation, invasion depth and vascular invasion. However, the genetic mechanisms underlying endometrial cancer have gradually been determined, due to developments in molecular biology, leading to the possibility of new methods of diagnosis and treatment planning. New candidate biomarkers for endometrial cancer include those for molecular epigenetic mutations, such as microRNAs. These biomarkers may permit earlier detection of endometrial cancer and prediction of outcomes and are likely to contribute to future personalized therapy for endometrial cancer.
Keywords: endometrial cancer; microsatellite instability; MSH6; DNA hypermethylation; CHFR; microRNA; Lynch syndrome; PTEN; K-ras; CA125
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MDPI and ACS Style
Banno, K.; Nogami, Y.; Kisu, I.; Yanokura, M.; Umene, K.; Masuda, K.; Kobayashi, Y.; Yamagami, W.; Susumu, N.; Aoki, D. Candidate Biomarkers for Genetic and Clinicopathological Diagnosis of Endometrial Cancer. Int. J. Mol. Sci. 2013, 14, 12123-12137.
Banno K, Nogami Y, Kisu I, Yanokura M, Umene K, Masuda K, Kobayashi Y, Yamagami W, Susumu N, Aoki D. Candidate Biomarkers for Genetic and Clinicopathological Diagnosis of Endometrial Cancer. International Journal of Molecular Sciences. 2013; 14(6):12123-12137.
Banno, Kouji; Nogami, Yuya; Kisu, Iori; Yanokura, Megumi; Umene, Kiyoko; Masuda, Kenta; Kobayashi, Yusuke; Yamagami, Wataru; Susumu, Nobuyuki; Aoki, Daisuke. 2013. "Candidate Biomarkers for Genetic and Clinicopathological Diagnosis of Endometrial Cancer." Int. J. Mol. Sci. 14, no. 6: 12123-12137.