Int. J. Mol. Sci. 2013, 14(5), 9205-9248; doi:10.3390/ijms14059205
Article

Excitation and Adaptation in Bacteria–a Model Signal Transduction System that Controls Taxis and Spatial Pattern Formation

1 School of Mathematics, University of Minnesota, Minneapolis,MN 55455, USA 2 Department of Mathematics, Ohio State University, Columbus, OH 43210, USA
* Author to whom correspondence should be addressed.
Received: 1 February 2013; in revised form: 20 March 2013 / Accepted: 22 March 2013 / Published: 26 April 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
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Abstract: The machinery for transduction of chemotactic stimuli in the bacterium E. coli is one of the most completely characterized signal transduction systems, and because of its relative simplicity, quantitative analysis of this system is possible. Here we discuss models which reproduce many of the important behaviors of the system. The important characteristics of the signal transduction system are excitation and adaptation, and the latter implies that the transduction system can function as a “derivative sensor” with respect to the ligand concentration in that the DC component of a signal is ultimately ignored if it is not too large. This temporal sensing mechanism provides the bacterium with a memory of its passage through spatially- or temporally-varying signal fields, and adaptation is essential for successful chemotaxis. We also discuss some of the spatial patterns observed in populations and indicate how cell-level behavior can be embedded in population-level descriptions.
Keywords: E. coli; Tar receptor; signal transduction; methylation; phosphorylation

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MDPI and ACS Style

Othmer, H.G.; Xin, X.; Xue, C. Excitation and Adaptation in Bacteria–a Model Signal Transduction System that Controls Taxis and Spatial Pattern Formation. Int. J. Mol. Sci. 2013, 14, 9205-9248.

AMA Style

Othmer HG, Xin X, Xue C. Excitation and Adaptation in Bacteria–a Model Signal Transduction System that Controls Taxis and Spatial Pattern Formation. International Journal of Molecular Sciences. 2013; 14(5):9205-9248.

Chicago/Turabian Style

Othmer, Hans G.; Xin, Xiangrong; Xue, Chuan. 2013. "Excitation and Adaptation in Bacteria–a Model Signal Transduction System that Controls Taxis and Spatial Pattern Formation." Int. J. Mol. Sci. 14, no. 5: 9205-9248.

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