Int. J. Mol. Sci. 2013, 14(4), 7932-7958; doi:10.3390/ijms14047932
Article

Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling

1 Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education,College of Chemistry, Beijing Normal University, Beijing 100875, China 2 Physics Department, West Virginia University, Morgantown, WV 26506-6315, USA
* Authors to whom correspondence should be addressed.
Received: 9 January 2013; in revised form: 5 March 2013 / Accepted: 27 March 2013 / Published: 11 April 2013
(This article belongs to the Special Issue Computational Modelling of Biological Membranes)
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Abstract: We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling.
Keywords: antimicrobial peptides; membrane; dissipative particle dynamics

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MDPI and ACS Style

Chen, L.; Jia, N.; Gao, L.; Fang, W.; Golubovic, L. Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling. Int. J. Mol. Sci. 2013, 14, 7932-7958.

AMA Style

Chen L, Jia N, Gao L, Fang W, Golubovic L. Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling. International Journal of Molecular Sciences. 2013; 14(4):7932-7958.

Chicago/Turabian Style

Chen, Licui; Jia, Nana; Gao, Lianghui; Fang, Weihai; Golubovic, Leonardo. 2013. "Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling." Int. J. Mol. Sci. 14, no. 4: 7932-7958.

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