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Int. J. Mol. Sci. 2013, 14(4), 6863-6888; doi:10.3390/ijms14046863
Review

Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders

1,†
 and 2,3,4,†,*
Received: 6 January 2013; in revised form: 1 March 2013 / Accepted: 15 March 2013 / Published: 26 March 2013
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Abstract: Notch signaling is a major pathway in cell fate decisions. Since the first reports showing the major role of Notch in embryonic development, a considerable and still growing literature further highlights its key contributions in various pathological processes during adult life. In particular, Notch is now considered as a major player in vascular homeostasis through the control of key cellular functions. In parallel, confounding evidence emerged that inflammatory responses regulate Notch signaling in vitro in endothelial cells, smooth muscle cells or vascular infiltrating cells and in vivo in vascular and inflammatory disorders and in cardiovascular diseases. This review presents how inflammation influences Notch in vascular cells and, reciprocally, emphasizes the functional role of Notch on inflammatory processes, notably by regulating key cell functions (differentiation, proliferation, apoptosis/survival, activation). Understanding how the disparity of Notch receptors and ligands impacts on vasculature biology remains critical for the design of relevant and adequate therapeutic strategies targeting Notch in this major pathological context.
Keywords: cardiovascular diseases; endothelial cells; inflammation; Notch signaling; signaling pathways; vascular cells cardiovascular diseases; endothelial cells; inflammation; Notch signaling; signaling pathways; vascular cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Quillard, T.; Charreau, B. Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders. Int. J. Mol. Sci. 2013, 14, 6863-6888.

AMA Style

Quillard T, Charreau B. Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders. International Journal of Molecular Sciences. 2013; 14(4):6863-6888.

Chicago/Turabian Style

Quillard, Thibaut; Charreau, Beatrice. 2013. "Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders." Int. J. Mol. Sci. 14, no. 4: 6863-6888.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert