Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2013, 14(4), 6571-6596; doi:10.3390/ijms14046571
Review

The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin

1
, 2
 and 1,*
Received: 1 February 2013; in revised form: 11 March 2013 / Accepted: 19 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)
View Full-Text   |   Download PDF [1529 KB, uploaded 19 June 2014]
Abstract: High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.
Keywords: serous ovarian cancer; fallopian tube; p53 signature; STIC; cellular transformation; cancer stem cells (CSC); tumor microenvironment serous ovarian cancer; fallopian tube; p53 signature; STIC; cellular transformation; cancer stem cells (CSC); tumor microenvironment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Kessler, M.; Fotopoulou, C.; Meyer, T. The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin. Int. J. Mol. Sci. 2013, 14, 6571-6596.

AMA Style

Kessler M, Fotopoulou C, Meyer T. The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin. International Journal of Molecular Sciences. 2013; 14(4):6571-6596.

Chicago/Turabian Style

Kessler, Mirjana; Fotopoulou, Christina; Meyer, Thomas. 2013. "The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin." Int. J. Mol. Sci. 14, no. 4: 6571-6596.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert