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The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin
Max Planck Institute for Infection Biology, Department of Molecular Biology, Charitéplatz 1, 11017 Berlin, Germany
Department of Gynecology, Charité, Campus Virchow Clinic, University Hospital Augustenburger Platz 1, 13353 Berlin, Germany
* Author to whom correspondence should be addressed.
Received: 1 February 2013; in revised form: 11 March 2013 / Accepted: 19 March 2013 / Published: 25 March 2013
Abstract: High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.
Keywords: serous ovarian cancer; fallopian tube; p53 signature; STIC; cellular transformation; cancer stem cells (CSC); tumor microenvironment
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Kessler, M.; Fotopoulou, C.; Meyer, T. The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin. Int. J. Mol. Sci. 2013, 14, 6571-6596.
Kessler M, Fotopoulou C, Meyer T. The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin. International Journal of Molecular Sciences. 2013; 14(4):6571-6596.
Kessler, Mirjana; Fotopoulou, Christina; Meyer, Thomas. 2013. "The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin." Int. J. Mol. Sci. 14, no. 4: 6571-6596.