Next Article in Journal
Noninvasive Metabolomic Profiling of Human Embryo Culture Media Using a Simple Spectroscopy Adjunct to Morphology for Embryo Assessment in in Vitro Fertilization (IVF)
Previous Article in Journal
Nuclear Lipid Microdomain as Place of Interaction between Sphingomyelin and DNA during Liver Regeneration
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(4), 6542-6555; doi:10.3390/ijms14046542

The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, Nijmegen 6525GA, The Netherlands
Nanobiophysics, MIRA Institute for Biomedical Technology and Technical Medicine & MESA+ Institute for Nanotechnology, University of Twente, Zuidhorst 164, Dienstweg 1, Enschede 7522ND, The Netherlands
Author to whom correspondence should be addressed.
Received: 15 February 2013 / Revised: 2 March 2013 / Accepted: 11 March 2013 / Published: 25 March 2013
View Full-Text   |   Download PDF [964 KB, uploaded 19 June 2014]   |  


Many processes regulating immune responses are initiated by G-protein coupled receptors (GPCRs) and report biochemical changes in the microenvironment. Dendritic cells (DCs) are the most potent antigen-presenting cells and crucial for the regulation of innate and adaptive immune responses. The lipid mediator Prostaglandin E2 (PGE2) via four GPCR subtypes (EP1-4) critically regulates DC generation, maturation and migration. The role of PGE2 signaling in DC biology was unraveled by the characterization of EP receptor subtype expression in DC progenitor cells and DCs, the identification of the signaling pathways initiated by these GPCR subtypes and the classification of DC responses to PGE2 at different stages of differentiation. Here, we review the advances in PGE2 signaling in DCs and describe the efforts still to be made to understand the spatio-temporal fine-tuning of PGE2 responses by DCs.
Keywords: PGE2; G-protein coupled receptors; EP2; EP4; dendritic cell PGE2; G-protein coupled receptors; EP2; EP4; dendritic cell

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

De Keijzer, S.; Meddens, M.B.M.; Torensma, R.; Cambi, A. The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle. Int. J. Mol. Sci. 2013, 14, 6542-6555.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top