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The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle
Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, Nijmegen 6525GA, The Netherlands
Nanobiophysics, MIRA Institute for Biomedical Technology and Technical Medicine & MESA+ Institute for Nanotechnology, University of Twente, Zuidhorst 164, Dienstweg 1, Enschede 7522ND, The Netherlands
* Author to whom correspondence should be addressed.
Received: 15 February 2013; in revised form: 2 March 2013 / Accepted: 11 March 2013 / Published: 25 March 2013
Abstract: Many processes regulating immune responses are initiated by G-protein coupled receptors (GPCRs) and report biochemical changes in the microenvironment. Dendritic cells (DCs) are the most potent antigen-presenting cells and crucial for the regulation of innate and adaptive immune responses. The lipid mediator Prostaglandin E2 (PGE2) via four GPCR subtypes (EP1-4) critically regulates DC generation, maturation and migration. The role of PGE2 signaling in DC biology was unraveled by the characterization of EP receptor subtype expression in DC progenitor cells and DCs, the identification of the signaling pathways initiated by these GPCR subtypes and the classification of DC responses to PGE2 at different stages of differentiation. Here, we review the advances in PGE2 signaling in DCs and describe the efforts still to be made to understand the spatio-temporal fine-tuning of PGE2 responses by DCs.
Keywords: PGE2; G-protein coupled receptors; EP2; EP4; dendritic cell
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De Keijzer, S.; Meddens, M.B.M.; Torensma, R.; Cambi, A. The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle. Int. J. Mol. Sci. 2013, 14, 6542-6555.
De Keijzer S, Meddens MBM, Torensma R, Cambi A. The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle. International Journal of Molecular Sciences. 2013; 14(4):6542-6555.
De Keijzer, Sandra; Meddens, Marjolein B.M.; Torensma, Ruurd; Cambi, Alessandra. 2013. "The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle." Int. J. Mol. Sci. 14, no. 4: 6542-6555.