Int. J. Mol. Sci. 2013, 14(3), 4841-4853; doi:10.3390/ijms14034841
Article

Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues

1 Division of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan 2 Gakubunkan Institute of Physiology and Medicine, Jobu University, 270-1 Shinmachi, Takasaki, Gunma 370-1393, Japan
* Author to whom correspondence should be addressed.
Received: 20 November 2012; in revised form: 7 February 2013 / Accepted: 15 February 2013 / Published: 1 March 2013
(This article belongs to the Special Issue Molecular Self-Assembly 2012)
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Abstract: The vascular endothelial growth factor (VEGF)-VEGF Receptor (VEGFR) system is an important pathway for regulation of angiogenesis. However, its evolutionary development, particularly the step from invertebrates to vertebrates, is still largely unknown. Here, we molecularly cloned the VEGFR-like gene from Halocynthia roretzi, a species belonging to the Tunicata, the chordate subphylum recently considered the sister group of vertebrates. The cDNA encoded a homolog of human VEGFR, including the transmembrane domain, and the tyrosine kinase domain with a kinase-insert region, which was designated S. sq VEGFR (GenBank AB374180). Similar to Tunicates including ascidians in the phylogenetic tree, the Amphioxus, another chordate, is located close to vertebrates. However, S. sq VEGFR has a higher homology than the Amphioxus VEGFR-like molecule (GenBank AB025557) to human VEGFR in the kinase domain-2 region. The S. sq VEGFR mRNA was expressed at highest levels in circulatory system-containing tissues, suggesting that S. sq VEGFR plays an important role in the formation or maintenance of circulatory system in Tunicates, Halocynthia roretzi.
Keywords: vascular endothelial growth factor receptor; Halocynthia roretzi; sea squirt; circulatory system

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MDPI and ACS Style

Samarghandian, S.; Shibuya, M. Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues. Int. J. Mol. Sci. 2013, 14, 4841-4853.

AMA Style

Samarghandian S, Shibuya M. Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues. International Journal of Molecular Sciences. 2013; 14(3):4841-4853.

Chicago/Turabian Style

Samarghandian, Saeed; Shibuya, Masabumi. 2013. "Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues." Int. J. Mol. Sci. 14, no. 3: 4841-4853.

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