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Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount
Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
Department of Molecular Hematology, University of Frankfurt, Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
* Author to whom correspondence should be addressed.
Received: 21 January 2013; in revised form: 17 February 2013 / Accepted: 21 February 2013 / Published: 1 March 2013
Abstract: The mitogen-activated protein kinase (MAPK) pathway is the canonical signaling pathway for many receptor tyrosine kinases, such as the Epidermal Growth Factor Receptor. Downstream of the receptors, this pathway involves the activation of a kinase cascade that culminates in a transcriptional response and affects processes, such as cell migration and adhesion. In addition, the strength and duration of the upstream signal also influence the mode of the cellular response that is switched on. Thus, the same components can in principle coordinate opposite responses, such as proliferation and differentiation. In recent years, it has become evident that MAPK signaling is regulated and fine-tuned by proteins that can bind to several MAPK signaling proteins simultaneously and, thereby, affect their function. These so-called MAPK scaffolding proteins are, thus, important coordinators of the signaling response in cells. In this review, we summarize the recent advances in the research on MAPK/extracellular signal-regulated kinase (ERK) pathway scaffolders. We will not only review the well-known members of the family, such as kinase suppressor of Ras (KSR), but also put a special focus on the function of the recently identified or less studied scaffolders, such as fibroblast growth factor receptor substrate 2, flotillin-1 and mitogen-activated protein kinase organizer 1.
Keywords: mitogen-activated protein kinase; signal transduction; growth factor; receptor tyrosine kinase; scaffolding proteins; cancer
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Meister, M.; Tomasovic, A.; Banning, A.; Tikkanen, R. Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount. Int. J. Mol. Sci. 2013, 14, 4854-4884.
Meister M, Tomasovic A, Banning A, Tikkanen R. Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount. International Journal of Molecular Sciences. 2013; 14(3):4854-4884.
Meister, Melanie; Tomasovic, Ana; Banning, Antje; Tikkanen, Ritva. 2013. "Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount." Int. J. Mol. Sci. 14, no. 3: 4854-4884.