Int. J. Mol. Sci. 2013, 14(3), 4722-4733; doi:10.3390/ijms14034722
Article

Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor?

1 School of Graduate Studies, Anhui Medical University, Hefei 230032, Anhui, China 2 Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, China
* Author to whom correspondence should be addressed.
Received: 21 January 2013; in revised form: 21 February 2013 / Accepted: 22 February 2013 / Published: 27 February 2013
PDF Full-text Download PDF Full-Text [1749 KB, uploaded 27 February 2013 11:54 CET]
Abstract: Oral or gastrointestinal mucositis is a frequent phenomenon in cancer patients receiving chemotherapy or radiotherapy. In addition, several clinical investigations have demonstrated in recent years that riboflavin laurate has the potential to protect the patients from the disease induced by chemotherapy or radiotherapy. In our studies, it is observed that riboflavin laurate can ameliorate either chemotherapy- or radiotherapy-induced toxicities on Helf cells, and the effect is greater than that of riboflavin. In addition, riboflavin laurate is able to transport through the Caco-2 cell monolayer as the prototype, indicating the protective effects may be produced by the prototype of riboflavin laurate, rather than simply by the released riboflavin.
Keywords: riboflavin laurate; oral or gastrointestinal mucositis; chemotherapy or radiotherapy; Caco-2 cell monolayer

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Xuan, Z.; An, Y.; Yang, D.; Wang, S.; Xu, Q.; Yuan, S. Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor? Int. J. Mol. Sci. 2013, 14, 4722-4733.

AMA Style

Xuan Z, An Y, Yang D, Wang S, Xu Q, Yuan S. Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor? International Journal of Molecular Sciences. 2013; 14(3):4722-4733.

Chicago/Turabian Style

Xuan, Zixue; An, Yinghong; Yang, Dexuan; Wang, Shanshan; Xu, Qishou; Yuan, Shoujun. 2013. "Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor?" Int. J. Mol. Sci. 14, no. 3: 4722-4733.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert