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Int. J. Mol. Sci. 2013, 14(3), 4722-4733; doi:10.3390/ijms14034722
Article

Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor?

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Received: 21 January 2013; in revised form: 21 February 2013 / Accepted: 22 February 2013 / Published: 27 February 2013
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Abstract: Oral or gastrointestinal mucositis is a frequent phenomenon in cancer patients receiving chemotherapy or radiotherapy. In addition, several clinical investigations have demonstrated in recent years that riboflavin laurate has the potential to protect the patients from the disease induced by chemotherapy or radiotherapy. In our studies, it is observed that riboflavin laurate can ameliorate either chemotherapy- or radiotherapy-induced toxicities on Helf cells, and the effect is greater than that of riboflavin. In addition, riboflavin laurate is able to transport through the Caco-2 cell monolayer as the prototype, indicating the protective effects may be produced by the prototype of riboflavin laurate, rather than simply by the released riboflavin.
Keywords: riboflavin laurate; oral or gastrointestinal mucositis; chemotherapy or radiotherapy; Caco-2 cell monolayer riboflavin laurate; oral or gastrointestinal mucositis; chemotherapy or radiotherapy; Caco-2 cell monolayer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xuan, Z.; An, Y.; Yang, D.; Wang, S.; Xu, Q.; Yuan, S. Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor? Int. J. Mol. Sci. 2013, 14, 4722-4733.

AMA Style

Xuan Z, An Y, Yang D, Wang S, Xu Q, Yuan S. Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor? International Journal of Molecular Sciences. 2013; 14(3):4722-4733.

Chicago/Turabian Style

Xuan, Zixue; An, Yinghong; Yang, Dexuan; Wang, Shanshan; Xu, Qishou; Yuan, Shoujun. 2013. "Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor?" Int. J. Mol. Sci. 14, no. 3: 4722-4733.



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