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Int. J. Mol. Sci. 2013, 14(3), 4705-4721; doi:10.3390/ijms14034705

Interplay between Hepatitis C Virus and Redox Cell Signaling

1,†,* , 2,†
, 2
, 3
, 3
 and 2,3
Received: 17 January 2013 / Revised: 13 February 2013 / Accepted: 17 February 2013 / Published: 26 February 2013
(This article belongs to the Special Issue Redox Signaling in Biology and Patho-Biology)
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Abstract: Hepatitis C virus (HCV) infects approximately 3% of the world’s population. Currently licensed treatment of HCV chronic infection with pegylated-interferon-α and ribavirin, is not fully effective against all HCV genotypes and is associated to severe side effects. Thus, development of novel therapeutics and identification of new targets for treatment of HCV infection is necessary. Current opinion is orienting to target antiviral drug discovery to the host cell pathways on which the virus relies, instead of against viral structures. Many intracellular signaling pathways manipulated by HCV for its own replication are finely regulated by the oxido-reductive (redox) state of the host cell. At the same time, HCV induces oxidative stress that has been found to affect both virus replication as well as progression and severity of HCV infection. A dual role, positive or negative, for the host cell oxidized conditions on HCV replication has been reported so far. This review examines current information about the effect of oxidative stress on HCV life cycle and the main redox-regulated intracellular pathways activated during HCV infection and involved in its replication.
Keywords: HCV; JFH-1; antioxidants; oxidative stress; GSH; MAPK; Akt HCV; JFH-1; antioxidants; oxidative stress; GSH; MAPK; Akt
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ruggieri, A.; Anticoli, S.; Nencioni, L.; Sgarbanti, R.; Garaci, E.; Palamara, A.T. Interplay between Hepatitis C Virus and Redox Cell Signaling. Int. J. Mol. Sci. 2013, 14, 4705-4721.

AMA Style

Ruggieri A, Anticoli S, Nencioni L, Sgarbanti R, Garaci E, Palamara AT. Interplay between Hepatitis C Virus and Redox Cell Signaling. International Journal of Molecular Sciences. 2013; 14(3):4705-4721.

Chicago/Turabian Style

Ruggieri, Anna; Anticoli, Simona; Nencioni, Lucia; Sgarbanti, Rossella; Garaci, Enrico; Palamara, Anna T. 2013. "Interplay between Hepatitis C Virus and Redox Cell Signaling." Int. J. Mol. Sci. 14, no. 3: 4705-4721.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert