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New Anti-Inflammatory Aromatic Components from Antrodia camphorata
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung 412, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 January 2013; in revised form: 5 February 2013 / Accepted: 10 February 2013 / Published: 26 February 2013
Abstract: Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol (1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol (4) and 2,3-methylenedioxy- 4-methoxy-5-methylphenol (5), were isolated from Antrodia camphorata. Our results support that compounds 1–5 potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production in a dose-dependent manner. The IC50 values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively.
Keywords: Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory
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Chen, Y.-C.; Chiu, H.-L.; Chao, C.-Y.; Lin, W.-H.; Chao, L.K.; Huang, G.-J.; Kuo, Y.-H. New Anti-Inflammatory Aromatic Components from Antrodia camphorata. Int. J. Mol. Sci. 2013, 14, 4629-4639.
Chen Y-C, Chiu H-L, Chao C-Y, Lin W-H, Chao LK, Huang G-J, Kuo Y-H. New Anti-Inflammatory Aromatic Components from Antrodia camphorata. International Journal of Molecular Sciences. 2013; 14(3):4629-4639.
Chen, Yu-Chang; Chiu, His-Lin; Chao, Che-Yi; Lin, Wen-Hsin; Chao, Louis K.; Huang, Guan-Jhong; Kuo, Yueh-Hsiung. 2013. "New Anti-Inflammatory Aromatic Components from Antrodia camphorata." Int. J. Mol. Sci. 14, no. 3: 4629-4639.