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Int. J. Mol. Sci. 2013, 14(3), 4629-4639; doi:10.3390/ijms14034629
Article

New Anti-Inflammatory Aromatic Components from Antrodia camphorata

1
, 1
, 2
, 3
, 4
, 1
 and 1,5,*
1 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan 2 Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung 412, Taiwan 3 School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan 4 Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan 5 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 January 2013 / Revised: 5 February 2013 / Accepted: 10 February 2013 / Published: 26 February 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol (1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol (4) and 2,3-methylenedioxy- 4-methoxy-5-methylphenol (5), were isolated from Antrodia camphorata. Our results support that compounds 15 potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production in a dose-dependent manner. The IC50 values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively.
Keywords: Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-C.; Chiu, H.-L.; Chao, C.-Y.; Lin, W.-H.; Chao, L.K.; Huang, G.-J.; Kuo, Y.-H. New Anti-Inflammatory Aromatic Components from Antrodia camphorata. Int. J. Mol. Sci. 2013, 14, 4629-4639.

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