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Int. J. Mol. Sci. 2013, 14(3), 4629-4639; doi:10.3390/ijms14034629
Article

New Anti-Inflammatory Aromatic Components from Antrodia camphorata

1
, 1
, 2
, 3
, 4
, 1
 and 1,5,*
Received: 9 January 2013; in revised form: 5 February 2013 / Accepted: 10 February 2013 / Published: 26 February 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol (1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol (4) and 2,3-methylenedioxy- 4-methoxy-5-methylphenol (5), were isolated from Antrodia camphorata. Our results support that compounds 15 potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production in a dose-dependent manner. The IC50 values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively.
Keywords: Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, Y.-C.; Chiu, H.-L.; Chao, C.-Y.; Lin, W.-H.; Chao, L.K.; Huang, G.-J.; Kuo, Y.-H. New Anti-Inflammatory Aromatic Components from Antrodia camphorata. Int. J. Mol. Sci. 2013, 14, 4629-4639.

AMA Style

Chen Y-C, Chiu H-L, Chao C-Y, Lin W-H, Chao LK, Huang G-J, Kuo Y-H. New Anti-Inflammatory Aromatic Components from Antrodia camphorata. International Journal of Molecular Sciences. 2013; 14(3):4629-4639.

Chicago/Turabian Style

Chen, Yu-Chang; Chiu, His-Lin; Chao, Che-Yi; Lin, Wen-Hsin; Chao, Louis K.; Huang, Guan-Jhong; Kuo, Yueh-Hsiung. 2013. "New Anti-Inflammatory Aromatic Components from Antrodia camphorata." Int. J. Mol. Sci. 14, no. 3: 4629-4639.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert