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Int. J. Mol. Sci. 2013, 14(3), 4629-4639; doi:10.3390/ijms14034629
Article

New Anti-Inflammatory Aromatic Components from Antrodia camphorata

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1
 and
1,5,*
1 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan 2 Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung 412, Taiwan 3 School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan 4 Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan 5 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 January 2013 / Revised: 5 February 2013 / Accepted: 10 February 2013 / Published: 26 February 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol (1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol (4) and 2,3-methylenedioxy- 4-methoxy-5-methylphenol (5), were isolated from Antrodia camphorata. Our results support that compounds 15 potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production in a dose-dependent manner. The IC50 values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively.
Keywords: Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chen, Y.-C.; Chiu, H.-L.; Chao, C.-Y.; Lin, W.-H.; Chao, L.K.; Huang, G.-J.; Kuo, Y.-H. New Anti-Inflammatory Aromatic Components from Antrodia camphorata. Int. J. Mol. Sci. 2013, 14, 4629-4639.

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