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Int. J. Mol. Sci. 2013, 14(3), 4629-4639; doi:10.3390/ijms14034629

New Anti-Inflammatory Aromatic Components from Antrodia camphorata

Received: 9 January 2013 / Revised: 5 February 2013 / Accepted: 10 February 2013 / Published: 26 February 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol (1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol (4) and 2,3-methylenedioxy- 4-methoxy-5-methylphenol (5), were isolated from Antrodia camphorata. Our results support that compounds 15 potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production in a dose-dependent manner. The IC50 values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively.
Keywords: Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory Antrodia camphorata; polyporaceae; benzenoid; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-C.; Chiu, H.-L.; Chao, C.-Y.; Lin, W.-H.; Chao, L.K.; Huang, G.-J.; Kuo, Y.-H. New Anti-Inflammatory Aromatic Components from Antrodia camphorata. Int. J. Mol. Sci. 2013, 14, 4629-4639.

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