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Int. J. Mol. Sci. 2013, 14(2), 4317-4325; doi:10.3390/ijms14024317
Article

Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis

1
, 2
, 2
, 3,*  and 4,5,*
Received: 9 January 2013; in revised form: 1 February 2013 / Accepted: 4 February 2013 / Published: 21 February 2013
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Abstract: Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 15, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
Keywords: diterpenoid; soft coral; Sinularia flexibilis diterpenoid; soft coral; Sinularia flexibilis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Su, C.-C.; Wong, B.-S.; Chin, C.; Wu, Y.-J.; Su, J.-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. Int. J. Mol. Sci. 2013, 14, 4317-4325.

AMA Style

Su C-C, Wong B-S, Chin C, Wu Y-J, Su J-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. International Journal of Molecular Sciences. 2013; 14(2):4317-4325.

Chicago/Turabian Style

Su, Ching-Chyuan; Wong, Bing-Sang; Chin, Chuen; Wu, Yu-Jen; Su, Jui-Hsin. 2013. "Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis." Int. J. Mol. Sci. 14, no. 2: 4317-4325.


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