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Int. J. Mol. Sci. 2013, 14(2), 4317-4325; doi:10.3390/ijms14024317

Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis

1
Department of Thoracic Cardiovascular Surgery, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan
2
Department of Deputy Superintendent, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan
3
Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan
4
National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan
5
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94450, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 9 January 2013 / Revised: 1 February 2013 / Accepted: 4 February 2013 / Published: 21 February 2013
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Abstract

Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 15, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
Keywords: diterpenoid; soft coral; Sinularia flexibilis diterpenoid; soft coral; Sinularia flexibilis
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Su, C.-C.; Wong, B.-S.; Chin, C.; Wu, Y.-J.; Su, J.-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. Int. J. Mol. Sci. 2013, 14, 4317-4325.

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