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Int. J. Mol. Sci. 2013, 14(2), 4317-4325; doi:10.3390/ijms14024317
Article

Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis

1
, 2
, 2
, 3,*  and 4,5,*
1 Department of Thoracic Cardiovascular Surgery, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan 2 Department of Deputy Superintendent, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan 3 Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan 4 National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan 5 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94450, Taiwan
* Authors to whom correspondence should be addressed.
Received: 9 January 2013 / Revised: 1 February 2013 / Accepted: 4 February 2013 / Published: 21 February 2013
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Abstract

Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 15, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
Keywords: diterpenoid; soft coral; Sinularia flexibilis diterpenoid; soft coral; Sinularia flexibilis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Su, C.-C.; Wong, B.-S.; Chin, C.; Wu, Y.-J.; Su, J.-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. Int. J. Mol. Sci. 2013, 14, 4317-4325.

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