Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis

doi:10.3390/ijms14024317

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Int. J. Mol. Sci. 2013, 14(2), 4317-4325; doi:10.3390/ijms14024317

Article

Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis

Ching-Chyuan Su¹, Bing-Sang Wong², Chuen Chin², Yu-Jen Wu^3,* and Jui-Hsin Su^4,5,*

¹ Department of Thoracic Cardiovascular Surgery, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan ² Department of Deputy Superintendent, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan ³ Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan ⁴ National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan ⁵ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94450, Taiwan

* Authors to whom correspondence should be addressed.

Received: 9 January 2013; in revised form: 1 February 2013 / Accepted: 4 February 2013 / Published: 21 February 2013

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Abstract: Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1–5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (¹H–¹H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.

Keywords: diterpenoid; soft coral; Sinularia flexibilis

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Cite This Article

MDPI and ACS Style

Su, C.-C.; Wong, B.-S.; Chin, C.; Wu, Y.-J.; Su, J.-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. Int. J. Mol. Sci. 2013, 14, 4317-4325.

AMA Style

Su C-C, Wong B-S, Chin C, Wu Y-J, Su J-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. International Journal of Molecular Sciences. 2013; 14(2):4317-4325.

Chicago/Turabian Style

Su, Ching-Chyuan; Wong, Bing-Sang; Chin, Chuen; Wu, Yu-Jen; Su, Jui-Hsin. 2013. "Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis." Int. J. Mol. Sci. 14, no. 2: 4317-4325.

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