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Int. J. Mol. Sci. 2013, 14(2), 4317-4325; doi:10.3390/ijms14024317

Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis

3,*  and 4,5,*
Received: 9 January 2013 / Revised: 1 February 2013 / Accepted: 4 February 2013 / Published: 21 February 2013
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Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 15, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
Keywords: diterpenoid; soft coral; Sinularia flexibilis diterpenoid; soft coral; Sinularia flexibilis
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Su, C.-C.; Wong, B.-S.; Chin, C.; Wu, Y.-J.; Su, J.-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. Int. J. Mol. Sci. 2013, 14, 4317-4325.

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