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Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
Department of Thoracic Cardiovascular Surgery, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan
Department of Deputy Superintendent, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan
Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94450, Taiwan
* Authors to whom correspondence should be addressed.
Received: 9 January 2013; in revised form: 1 February 2013 / Accepted: 4 February 2013 / Published: 21 February 2013
Abstract: Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1–5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
Keywords: diterpenoid; soft coral; Sinularia flexibilis
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Su, C.-C.; Wong, B.-S.; Chin, C.; Wu, Y.-J.; Su, J.-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. Int. J. Mol. Sci. 2013, 14, 4317-4325.
Su C-C, Wong B-S, Chin C, Wu Y-J, Su J-H. Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis. International Journal of Molecular Sciences. 2013; 14(2):4317-4325.
Su, Ching-Chyuan; Wong, Bing-Sang; Chin, Chuen; Wu, Yu-Jen; Su, Jui-Hsin. 2013. "Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis." Int. J. Mol. Sci. 14, no. 2: 4317-4325.