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Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds
Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan 608-737, Korea
* Author to whom correspondence should be addressed.
Received: 16 November 2012; in revised form: 10 January 2013 / Accepted: 11 January 2013 / Published: 24 January 2013
Abstract: Inhibition of apoptosis leads to activation of cell survival factors (e.g., AKT) causes continuous cell proliferation in cancer. Apoptosis, the major form of cellular suicide, is central to various physiological processes and the maintenance of homeostasis in multicellular organisms. A number of discoveries have clarified the molecular mechanism of apoptosis, thus clarifying the link between apoptosis and cell survival factors, which has a therapeutic outcome. Induction of apoptosis and inhibition of cell survival by anticancer agents has been shown to correlate with tumor response. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, necrosis and senescence; the mechanism of cell death depends on the magnitude of DNA damage following exposure to various anticancer agents. Apoptosis is mainly regulated by cell survival and proliferating signaling molecules. As a new therapeutic strategy, alternative types of cell death might be exploited to control and eradicate cancer cells. This review discusses the signaling of apoptosis and cell survival, as well as the potential contribution of marine bioactive compounds, suggesting that new therapeutic strategies might follow.
Keywords: apoptosis; cell survival; AKT; Bax; marine compounds
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MDPI and ACS Style
Kalimuthu, S.; Se-Kwon, K. Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds. Int. J. Mol. Sci. 2013, 14, 2334-2354.
Kalimuthu S, Se-Kwon K. Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds. International Journal of Molecular Sciences. 2013; 14(2):2334-2354.
Kalimuthu, Senthilkumar; Se-Kwon, Kim. 2013. "Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds." Int. J. Mol. Sci. 14, no. 2: 2334-2354.