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Int. J. Mol. Sci. 2013, 14(2), 2355-2369; doi:10.3390/ijms14022355

Connecting Chromatin Modifying Factors to DNA Damage Response

1,2,3
,
1,2,3
,
4,5,* and 1,2,3,*
1
Cancer Research Institute, Central South University, Changsha 410078, Hunan, China
2
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, Hunan, China
3
Key Laboratory of Carcinogenesis Principal, Ministry of Health, Changsha 410078, Hunan, China
4
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
5
Center for Medicine Science, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
*
Authors to whom correspondence should be addressed.
Received: 24 September 2012 / Revised: 11 December 2012 / Accepted: 9 January 2013 / Published: 24 January 2013
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Abstract

Cells are constantly damaged by factors that can induce DNA damage. Eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin during the DNA damage response (DDR). Chromatin-remodeling complexes use the energy from ATP hydrolysis to remodel nucleosomes and have well-established functions in transcription. Emerging lines of evidence indicate that chromatin-remodeling complexes are important and may remodel nucleosomes during DNA damage repair. New studies also reveal that ATP-dependent chromatin remodeling is involved in cell cycle progression, signal transduction pathways, and interaction and modification of DDR-related proteins that are specifically and intimately connected with the process of DNA damage. This article summarizes the recent advances in our understanding of the interplay between chromatin remodeling and DNA damage response.
Keywords: chromatin-remodeling factor; DNA damage response; signaling transduction pathway; cell cycle; protein interaction; protein modification; double strand breaks chromatin-remodeling factor; DNA damage response; signaling transduction pathway; cell cycle; protein interaction; protein modification; double strand breaks
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lai, W.; Li, H.; Liu, S.; Tao, Y. Connecting Chromatin Modifying Factors to DNA Damage Response. Int. J. Mol. Sci. 2013, 14, 2355-2369.

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