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Connecting Chromatin Modifying Factors to DNA Damage Response
Cancer Research Institute, Central South University, Changsha 410078, Hunan, China
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, Hunan, China
Key Laboratory of Carcinogenesis Principal, Ministry of Health, Changsha 410078, Hunan, China
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
Center for Medicine Science, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
* Authors to whom correspondence should be addressed.
Received: 24 September 2012; in revised form: 11 December 2012 / Accepted: 9 January 2013 / Published: 24 January 2013
Abstract: Cells are constantly damaged by factors that can induce DNA damage. Eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin during the DNA damage response (DDR). Chromatin-remodeling complexes use the energy from ATP hydrolysis to remodel nucleosomes and have well-established functions in transcription. Emerging lines of evidence indicate that chromatin-remodeling complexes are important and may remodel nucleosomes during DNA damage repair. New studies also reveal that ATP-dependent chromatin remodeling is involved in cell cycle progression, signal transduction pathways, and interaction and modification of DDR-related proteins that are specifically and intimately connected with the process of DNA damage. This article summarizes the recent advances in our understanding of the interplay between chromatin remodeling and DNA damage response.
Keywords: chromatin-remodeling factor; DNA damage response; signaling transduction pathway; cell cycle; protein interaction; protein modification; double strand breaks
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Cite This Article
MDPI and ACS Style
Lai, W.; Li, H.; Liu, S.; Tao, Y. Connecting Chromatin Modifying Factors to DNA Damage Response. Int. J. Mol. Sci. 2013, 14, 2355-2369.
Lai W, Li H, Liu S, Tao Y. Connecting Chromatin Modifying Factors to DNA Damage Response. International Journal of Molecular Sciences. 2013; 14(2):2355-2369.
Lai, Weiwei; Li, Hongde; Liu, Shuang; Tao, Yongguang. 2013. "Connecting Chromatin Modifying Factors to DNA Damage Response." Int. J. Mol. Sci. 14, no. 2: 2355-2369.