Int. J. Mol. Sci. 2013, 14(2), 2282-2302; doi:10.3390/ijms14022282
Review

Thermotropic and Barotropic Phase Behavior of Phosphatidylcholine Bilayers

Received: 21 December 2012; in revised form: 11 January 2013 / Accepted: 15 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue Phospholipids: Molecular Sciences 2012)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Bilayers formed by phospholipids are frequently used as model biological membranes in various life science studies. A characteristic feature of phospholipid bilayers is to undergo a structural change called a phase transition in response to environmental changes of their surroundings. In this review, we focus our attention on phase transitions of some major phospholipids contained in biological membranes, phosphatidylcholines (PCs), depending on temperature and pressure. Bilayers of dipalmitoylphosphatidylcholine (DPPC), which is the most representative lipid in model membrane studies, will first be explained. Then, the bilayer phase behavior of various kinds of PCs with different molecular structures is revealed from the temperature–pressure phase diagrams, and the difference in phase stability among these PC bilayers is discussed in connection with the molecular structure of the PC molecules. Furthermore, the solvent effect on the phase behavior is also described briefly.
Keywords: bilayer; lipid membrane; phase diagram; phase transition; phosphatidylcholine; pressure
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MDPI and ACS Style

Matsuki, H.; Goto, M.; Tada, K.; Tamai, N. Thermotropic and Barotropic Phase Behavior of Phosphatidylcholine Bilayers. Int. J. Mol. Sci. 2013, 14, 2282-2302.

AMA Style

Matsuki H, Goto M, Tada K, Tamai N. Thermotropic and Barotropic Phase Behavior of Phosphatidylcholine Bilayers. International Journal of Molecular Sciences. 2013; 14(2):2282-2302.

Chicago/Turabian Style

Matsuki, Hitoshi; Goto, Masaki; Tada, Kaori; Tamai, Nobutake. 2013. "Thermotropic and Barotropic Phase Behavior of Phosphatidylcholine Bilayers." Int. J. Mol. Sci. 14, no. 2: 2282-2302.

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