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Bioresorbable Drug-Eluting Magnesium-Alloy Scaffold for Treatment of Coronary Artery Disease
Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam 3015 GD, The Netherlands
Heart Institute (InCor), University of São Paulo Medical School, Sao Paulo 05403-000, Brazil
Department of Cardiology, Fujita Health University Hospital, Tokyo 470-1192, Japan
Department of Cardiology, Imperial College London, London SW7 2AZ, UK
Städtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss 41464, Germany
BIOTRONIK AG, Bülach CH-8180, Switzerland
* Author to whom correspondence should be addressed.
Received: 21 October 2013; in revised form: 3 December 2013 / Accepted: 12 December 2013 / Published: 16 December 2013
Abstract: The introduction of metallic drug-eluting stents has reduced the risk of restenosis and widened the indications of percutaneous coronary intervention in treatment of coronary artery disease. However, this medical device can induce hypersensitive reaction that interferes with the endothelialization and healing process resulting in late persistent or acquired malapposition of the permanent metallic implant. Delayed endotheliaization and malapposition may lead to late and very late stent thrombosis. Bioresorbable scaffolds (BRS) have been introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Magnesium is an essential mineral needed for a variety of physiological functions in the human body and its bioresorbable alloy has the strength-to-weight ratio comparable with that of strong aluminum alloys and alloy steels. The aim of this review is to present the new developments in Magnesium BRS technology, to describe its clinical application and to discuss the future prospects of this innovative therapy.
Keywords: bioresorbable scaffold; drug-eluting stent; bioabsorbable; biodegradable; coronary artery disease; magnesium
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Campos, C.M.; Muramatsu, T.; Iqbal, J.; Zhang, Y.-J.; Onuma, Y.; Garcia-Garcia, H.M.; Haude, M.; Lemos, P.A.; Warnack, B.; Serruys, P.W. Bioresorbable Drug-Eluting Magnesium-Alloy Scaffold for Treatment of Coronary Artery Disease. Int. J. Mol. Sci. 2013, 14, 24492-24500.
Campos CM, Muramatsu T, Iqbal J, Zhang Y-J, Onuma Y, Garcia-Garcia HM, Haude M, Lemos PA, Warnack B, Serruys PW. Bioresorbable Drug-Eluting Magnesium-Alloy Scaffold for Treatment of Coronary Artery Disease. International Journal of Molecular Sciences. 2013; 14(12):24492-24500.
Campos, Carlos M.; Muramatsu, Takashi; Iqbal, Javaid; Zhang, Yao-Jun; Onuma, Yoshinobu; Garcia-Garcia, Hector M.; Haude, Michael; Lemos, Pedro A.; Warnack, Boris; Serruys, Patrick W. 2013. "Bioresorbable Drug-Eluting Magnesium-Alloy Scaffold for Treatment of Coronary Artery Disease." Int. J. Mol. Sci. 14, no. 12: 24492-24500.