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Int. J. Mol. Sci. 2013, 14(10), 20983-21005; doi:10.3390/ijms141020983
Review

Biofilm Matrix and Its Regulation in Pseudomonas aeruginosa

 and
*
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No.3, 1st Beichen West Road, Chaoyang District, Beijing 100101, China
* Author to whom correspondence should be addressed.
Received: 21 August 2013 / Revised: 29 September 2013 / Accepted: 9 October 2013 / Published: 18 October 2013
(This article belongs to the Special Issue Biofilms: Extracellular Bastions of Bacteria)
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Abstract

Biofilms are communities of microorganisms embedded in extracellular polymeric substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free-living planktonic counterparts, such as different physiology and high resistance to immune system and antibiotics that render biofilm a source of chronic and persistent infections. A deeper understanding of biofilms will ultimately provide insights into the development of alternative treatment for biofilm infections. The opportunistic pathogen Pseudomonas aeruginosa, a model bacterium for biofilm research, is notorious for its ability to cause chronic infections by its high level of drug resistance involving the formation of biofilms. In this review, we summarize recent advances in biofilm formation, focusing on the biofilm matrix and its regulation in P. aeruginosa, aiming to provide resources for the understanding and control of bacterial biofilms.
Keywords: Pseudomonas aeruginosa; biofilm matrix; exopolysaccharides; gene regulation; anti-biofilm Pseudomonas aeruginosa; biofilm matrix; exopolysaccharides; gene regulation; anti-biofilm
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wei, Q.; Ma, L.Z. Biofilm Matrix and Its Regulation in Pseudomonas aeruginosa. Int. J. Mol. Sci. 2013, 14, 20983-21005.

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