Int. J. Mol. Sci. 2013, 14(10), 19651-19669; doi:10.3390/ijms141019651
Review

Advanced Knowledge of Three Important Classes of Grape Phenolics: Anthocyanins, Stilbenes and Flavonols

1 Consiglio per la Ricerca e la Sperimentazione in Agricoltura-Centro di Ricerca per la Viticoltura (CRA-VIT), Viale XXVIII aprile, Conegliano 26-31015, TV, Italy 2 IASMA Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige 38010, TN, Italy
* Author to whom correspondence should be addressed.
Received: 17 July 2013; in revised form: 11 September 2013 / Accepted: 12 September 2013 / Published: 27 September 2013
(This article belongs to the Special Issue Molecular Research in Plant Secondary Metabolism)
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Abstract: Grape is qualitatively and quantitatively very rich in polyphenols. In particular, anthocyanins, flavonols and stilbene derivatives play very important roles in plant metabolism, thanks to their peculiar characteristics. Anthocyanins are responsible for the color of red grapes and wines and confer organoleptic characteristics on the wine. They are used for chemotaxonomic studies and to evaluate the polyphenolic ripening stage of grape. They are natural colorants, have antioxidant, antimicrobial and anticarcinogenic activity, exert protective effects on the human cardiovascular system, and are used in the food and pharmaceutical industries. Stilbenes are vine phytoalexins present in grape berries and associated with the beneficial effects of drinking wine. The principal stilbene, resveratrol, is characterized by anticancer, antioxidant, anti-inflammatory and cardioprotective activity. Resveratrol dimers and oligomers also occur in grape, and are synthetized by the vine as active defenses against exogenous attack, or produced by extracellular enzymes released from pathogens in an attempt to eliminate undesirable toxic compounds. Flavonols are a ubiquitous class of flavonoids with photo-protection and copigmentation (together with anthocyanins) functions. The lack of expression of the enzyme flavonoid 3',5'-hydroxylase in white grapes restricts the presence of these compounds to quercetin, kaempferol and isorhamnetin derivatives, whereas red grapes usually also contain myricetin, laricitrin and syringetin derivatives. In the last ten years, the technological development of analytical instrumentation, particularly mass spectrometry, has led to great improvements and further knowledge of the chemistry of these compounds. In this review, the biosynthesis and biological role of these grape polyphenols are briefly introduced, together with the latest knowledge of their chemistry.
Keywords: grape; polyphenols; anthocyanins; stilbenes; flavonols

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MDPI and ACS Style

Flamini, R.; Mattivi, F.; Rosso, M.D.; Arapitsas, P.; Bavaresco, L. Advanced Knowledge of Three Important Classes of Grape Phenolics: Anthocyanins, Stilbenes and Flavonols. Int. J. Mol. Sci. 2013, 14, 19651-19669.

AMA Style

Flamini R, Mattivi F, Rosso MD, Arapitsas P, Bavaresco L. Advanced Knowledge of Three Important Classes of Grape Phenolics: Anthocyanins, Stilbenes and Flavonols. International Journal of Molecular Sciences. 2013; 14(10):19651-19669.

Chicago/Turabian Style

Flamini, Riccardo; Mattivi, Fulvio; Rosso, Mirko D.; Arapitsas, Panagiotis; Bavaresco, Luigi. 2013. "Advanced Knowledge of Three Important Classes of Grape Phenolics: Anthocyanins, Stilbenes and Flavonols." Int. J. Mol. Sci. 14, no. 10: 19651-19669.

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