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Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties
Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
Department of Chemistry, Yogananda Inistitute of Technology and Science, 517520 Tirupati, India
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, UCSI University, No.1, Jalan Menera Gading, 56000 Cheras, Kuala Lumpur, Malaysia
Department of Chemistry, Sri Venkateswara University, 517502 Tirupati, India
Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Department of Food Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 19 November 2012; in revised form: 10 December 2012 / Accepted: 24 December 2012 / Published: 16 January 2013
Abstract: Polymer supported dichlorophosphate (PEG-OPOCl2) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their anti-cancer activity are evaluated.
Keywords: cytotoxicity properties; bisindolylmethanes; dibisindolylmethanes; green catalyst
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Naidu, K.R.M.; Khalivulla, S.I.; Rasheed, S.; Fakurazi, S.; Arulselvan, P.; Lasekan, O.; Abas, F. Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties. Int. J. Mol. Sci. 2013, 14, 1843-1853.
Naidu KRM, Khalivulla SI, Rasheed S, Fakurazi S, Arulselvan P, Lasekan O, Abas F. Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties. International Journal of Molecular Sciences. 2013; 14(1):1843-1853.
Naidu, Kalla R.M.; Khalivulla, Shaik I.; Rasheed, Syed; Fakurazi, Sharida; Arulselvan, Palanisamy; Lasekan, Ola; Abas, Faridah. 2013. "Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties." Int. J. Mol. Sci. 14, no. 1: 1843-1853.