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Int. J. Mol. Sci. 2013, 14(1), 1843-1853; doi:10.3390/ijms14011843
Article

Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties

1,2
, 3
, 4
, 5,6
, 6
, 1,*  and 7
1 Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia 2 Department of Chemistry, Yogananda Inistitute of Technology and Science, 517520 Tirupati, India 3 Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, UCSI University, No.1, Jalan Menera Gading, 56000 Cheras, Kuala Lumpur, Malaysia 4 Department of Chemistry, Sri Venkateswara University, 517502 Tirupati, India 5 Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia 6 Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia 7 Department of Food Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 19 November 2012 / Revised: 10 December 2012 / Accepted: 24 December 2012 / Published: 16 January 2013
(This article belongs to the Section Bioinorganic Chemistry)
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Abstract

Polymer supported dichlorophosphate (PEG-OPOCl2) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their anti-cancer activity are evaluated.
Keywords: cytotoxicity properties; bisindolylmethanes; dibisindolylmethanes; green catalyst cytotoxicity properties; bisindolylmethanes; dibisindolylmethanes; green catalyst
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Naidu, K.R.M.; Khalivulla, S.I.; Rasheed, S.; Fakurazi, S.; Arulselvan, P.; Lasekan, O.; Abas, F. Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties. Int. J. Mol. Sci. 2013, 14, 1843-1853.

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