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Int. J. Mol. Sci. 2013, 14(1), 1843-1853; doi:10.3390/ijms14011843
Article

Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties

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Received: 19 November 2012 / Revised: 10 December 2012 / Accepted: 24 December 2012 / Published: 16 January 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Polymer supported dichlorophosphate (PEG-OPOCl2) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their anti-cancer activity are evaluated.
Keywords: cytotoxicity properties; bisindolylmethanes; dibisindolylmethanes; green catalyst cytotoxicity properties; bisindolylmethanes; dibisindolylmethanes; green catalyst
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Naidu, K.R.M.; Khalivulla, S.I.; Rasheed, S.; Fakurazi, S.; Arulselvan, P.; Lasekan, O.; Abas, F. Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties. Int. J. Mol. Sci. 2013, 14, 1843-1853.

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