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Organic Nitrates Favor Regression of Left Ventricular Hypertrophy in Hypertensive Patients on Chronic Peritoneal Dialysis
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
Nephrology Faculty, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing 100020, China
* Author to whom correspondence should be addressed.
Received: 10 September 2012; in revised form: 4 December 2012 / Accepted: 28 December 2012 / Published: 7 January 2013
Abstract: The aim of the study was to evaluate the effect of nitrates on left ventricular hypertrophy (LVH) in hypertensive patients on chronic peritoneal dialysis (PD). Sixty-four PD patients with hypertension were enrolled in this study. All patients accepted antihypertensive drugs at baseline. Thirty-two patients (nitrate group) took isosorbide mononitrate for 24 weeks. The remaining 32 patients (non-nitrate group) took other antihypertensive drugs. Blood pressure (BP), left ventricular mass index (LVMI) and plasma asymmetric dimethylarginine (ADMA) were monitored. Subjects with normal renal function were included as the control group (n = 30). At baseline, plasma ADMA levels in PD patients were significantly higher than the control group, but there was no significant difference in plasma ADMA levels between the two groups. At the end of the 24-week period, BP, LVMI, LVH prevalence and plasma ADMA levels in the nitrate group were significantly lower than those in the non-nitrate group. BP did not show a significant difference between 12 and 24 weeks in the nitrate group with a reduced need for other medication. Logistic regression analysis showed that nitrate supplementation and SBP reduction were independent risk factors of LVMI change in PD patients after adjusting for age, gender, diabetes history and CCB supplementation. It was concluded that organic nitrates favor regression of LVH in hypertensive patients on chronic peritoneal dialysis, and nitrates may be considered for use before employing the five other antihypertensive agents other than nitrates.
Keywords: nitrate; ADMA; hypertension; left ventricular hypertrophy; renal dialysis
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Li, H.; Wang, S. Organic Nitrates Favor Regression of Left Ventricular Hypertrophy in Hypertensive Patients on Chronic Peritoneal Dialysis. Int. J. Mol. Sci. 2013, 14, 1069-1079.
Li H, Wang S. Organic Nitrates Favor Regression of Left Ventricular Hypertrophy in Hypertensive Patients on Chronic Peritoneal Dialysis. International Journal of Molecular Sciences. 2013; 14(1):1069-1079.
Li, Han; Wang, Shixiang. 2013. "Organic Nitrates Favor Regression of Left Ventricular Hypertrophy in Hypertensive Patients on Chronic Peritoneal Dialysis." Int. J. Mol. Sci. 14, no. 1: 1069-1079.