Int. J. Mol. Sci. 2012, 13(9), 11954-11973; doi:10.3390/ijms130911954
Review

The Emerging Roles of ATP-Dependent Chromatin Remodeling Enzymes in Nucleotide Excision Repair

email, email and * email
Received: 2 August 2012; in revised form: 30 August 2012 / Accepted: 31 August 2012 / Published: 20 September 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: DNA repair in eukaryotic cells takes place in the context of chromatin, where DNA, including damaged DNA, is tightly packed into nucleosomes and higher order chromatin structures. Chromatin intrinsically restricts accessibility of DNA repair proteins to the damaged DNA and impacts upon the overall rate of DNA repair. Chromatin is highly responsive to DNA damage and undergoes specific remodeling to facilitate DNA repair. How damaged DNA is accessed, repaired and restored to the original chromatin state, and how chromatin remodeling coordinates these processes in vivo, remains largely unknown. ATP-dependent chromatin remodelers (ACRs) are the master regulators of chromatin structure and dynamics. Conserved from yeast to humans, ACRs utilize the energy of ATP to reorganize packing of chromatin and control DNA accessibility by sliding, ejecting or restructuring nucleosomes. Several studies have demonstrated that ATP-dependent remodeling activity of ACRs plays important roles in coordination of spatio-temporal steps of different DNA repair pathways in chromatin. This review focuses on the role of ACRs in regulation of various aspects of nucleotide excision repair (NER) in the context of chromatin. We discuss current understanding of ATP-dependent chromatin remodeling by various subfamilies of remodelers and regulation of the NER pathway in vivo.
Keywords: DNA repair; DNA damage accessibility; nucleosome
PDF Full-text Download PDF Full-Text [484 KB, Updated Version, uploaded 19 June 2014 04:27 CEST]
The original version is still available [484 KB, uploaded 19 June 2014 04:27 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Czaja, W.; Mao, P.; Smerdon, M.J. The Emerging Roles of ATP-Dependent Chromatin Remodeling Enzymes in Nucleotide Excision Repair. Int. J. Mol. Sci. 2012, 13, 11954-11973.

AMA Style

Czaja W, Mao P, Smerdon MJ. The Emerging Roles of ATP-Dependent Chromatin Remodeling Enzymes in Nucleotide Excision Repair. International Journal of Molecular Sciences. 2012; 13(9):11954-11973.

Chicago/Turabian Style

Czaja, Wioletta; Mao, Peng; Smerdon, Michael J. 2012. "The Emerging Roles of ATP-Dependent Chromatin Remodeling Enzymes in Nucleotide Excision Repair." Int. J. Mol. Sci. 13, no. 9: 11954-11973.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert