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Int. J. Mol. Sci. 2012, 13(9), 11773-11782; doi:10.3390/ijms130911773
Article

Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice

1
,
1,2,* , 1,2
,
1
,
1
 and
1,3
1 School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China 2 School of Forestry, Northeast Forestry University, Harbin 150040, China 3 National Research Center of Soybean Engineering and Technology, Northeast Agriculture University, Harbin 150030, China
* Author to whom correspondence should be addressed.
Received: 2 August 2012 / Revised: 28 August 2012 / Accepted: 3 September 2012 / Published: 18 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body 60Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.
Keywords: anthocyanin; Lonicera caerulea var. edulis; 60Coγ radiation; mice; radioprotection anthocyanin; Lonicera caerulea var. edulis; 60Coγ radiation; mice; radioprotection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhao, H.; Wang, Z.; Ma, F.; Yang, X.; Cheng, C.; Yao, L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. Int. J. Mol. Sci. 2012, 13, 11773-11782.

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