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Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice
School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China
School of Forestry, Northeast Forestry University, Harbin 150040, China
National Research Center of Soybean Engineering and Technology, Northeast Agriculture University, Harbin 150030, China
* Author to whom correspondence should be addressed.
Received: 2 August 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 18 September 2012
Abstract: The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body 60Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.
Keywords: anthocyanin; Lonicera caerulea var. edulis; 60Coγ radiation; mice; radioprotection
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MDPI and ACS Style
Zhao, H.; Wang, Z.; Ma, F.; Yang, X.; Cheng, C.; Yao, L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. Int. J. Mol. Sci. 2012, 13, 11773-11782.
Zhao H, Wang Z, Ma F, Yang X, Cheng C, Yao L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. International Journal of Molecular Sciences. 2012; 13(9):11773-11782.
Zhao, Haitian; Wang, Zhenyu; Ma, Fengming; Yang, Xin; Cheng, Cuilin; Yao, Lei. 2012. "Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice." Int. J. Mol. Sci. 13, no. 9: 11773-11782.