Int. J. Mol. Sci. 2012, 13(9), 11773-11782; doi:10.3390/ijms130911773
Article

Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice

1 School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China 2 School of Forestry, Northeast Forestry University, Harbin 150040, China 3 National Research Center of Soybean Engineering and Technology, Northeast Agriculture University, Harbin 150030, China
* Author to whom correspondence should be addressed.
Received: 2 August 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 18 September 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
PDF Full-text Download PDF Full-Text [186 KB, uploaded 19 September 2012 14:36 CEST]
Abstract: The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body 60Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.
Keywords: anthocyanin; Lonicera caerulea var. edulis; 60Coγ radiation; mice; radioprotection

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Zhao, H.; Wang, Z.; Ma, F.; Yang, X.; Cheng, C.; Yao, L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. Int. J. Mol. Sci. 2012, 13, 11773-11782.

AMA Style

Zhao H, Wang Z, Ma F, Yang X, Cheng C, Yao L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. International Journal of Molecular Sciences. 2012; 13(9):11773-11782.

Chicago/Turabian Style

Zhao, Haitian; Wang, Zhenyu; Ma, Fengming; Yang, Xin; Cheng, Cuilin; Yao, Lei. 2012. "Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice." Int. J. Mol. Sci. 13, no. 9: 11773-11782.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert