Abstract: The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body 60Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.
Keywords: anthocyanin; Lonicera caerulea var. edulis; 60Coγ radiation; mice; radioprotection
Export to BibTeX
MDPI and ACS Style
Zhao, H.; Wang, Z.; Ma, F.; Yang, X.; Cheng, C.; Yao, L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. Int. J. Mol. Sci. 2012, 13, 11773-11782.
Zhao H, Wang Z, Ma F, Yang X, Cheng C, Yao L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. International Journal of Molecular Sciences. 2012; 13(9):11773-11782.
Zhao, Haitian; Wang, Zhenyu; Ma, Fengming; Yang, Xin; Cheng, Cuilin; Yao, Lei. 2012. "Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice." Int. J. Mol. Sci. 13, no. 9: 11773-11782.