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Int. J. Mol. Sci. 2012, 13(9), 11773-11782; doi:10.3390/ijms130911773
Article

Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice

1
,
1,2,* , 1,2
,
1
,
1
 and
1,3
1 School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China 2 School of Forestry, Northeast Forestry University, Harbin 150040, China 3 National Research Center of Soybean Engineering and Technology, Northeast Agriculture University, Harbin 150030, China
* Author to whom correspondence should be addressed.
Received: 2 August 2012 / Revised: 28 August 2012 / Accepted: 3 September 2012 / Published: 18 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body 60Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.
Keywords: anthocyanin; Lonicera caerulea var. edulis; 60Coγ radiation; mice; radioprotection anthocyanin; Lonicera caerulea var. edulis; 60Coγ radiation; mice; radioprotection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zhao, H.; Wang, Z.; Ma, F.; Yang, X.; Cheng, C.; Yao, L. Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice. Int. J. Mol. Sci. 2012, 13, 11773-11782.

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