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Int. J. Mol. Sci. 2012, 13(8), 10359-10367; doi:10.3390/ijms130810359
Article

Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan

1,* , 1
 and
2,*
1 Department of Biological Sciences and Technology, National University of Tainan, 33 sec. 2 Su-Lin St., Tainan 700, Taiwan 2 Institute of Cosmetics Science, Chia Nan University of Pharmacy and Science, 60 sec. 1 Erh-Jen RD, Jen-Te, Tainan 717, Taiwan
* Authors to whom correspondence should be addressed.
Received: 4 July 2012 / Revised: 8 August 2012 / Accepted: 9 August 2012 / Published: 20 August 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.
Keywords: Caesalpinia sappan; inhibition; melanogenesis; sappanone A; tyrosinase Caesalpinia sappan; inhibition; melanogenesis; sappanone A; tyrosinase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chang, T.-S.; Chao, S.-Y.; Ding, H.-Y. Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan. Int. J. Mol. Sci. 2012, 13, 10359-10367.

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