Int. J. Mol. Sci. 2012, 13(8), 10359-10367; doi:10.3390/ijms130810359
Article

Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan

1 Department of Biological Sciences and Technology, National University of Tainan, 33 sec. 2 Su-Lin St., Tainan 700, Taiwan 2 Institute of Cosmetics Science, Chia Nan University of Pharmacy and Science, 60 sec. 1 Erh-Jen RD, Jen-Te, Tainan 717, Taiwan
* Authors to whom correspondence should be addressed.
Received: 4 July 2012; in revised form: 8 August 2012 / Accepted: 9 August 2012 / Published: 20 August 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.
Keywords: Caesalpinia sappan; inhibition; melanogenesis; sappanone A; tyrosinase

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MDPI and ACS Style

Chang, T.-S.; Chao, S.-Y.; Ding, H.-Y. Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan. Int. J. Mol. Sci. 2012, 13, 10359-10367.

AMA Style

Chang T-S, Chao S-Y, Ding H-Y. Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan. International Journal of Molecular Sciences. 2012; 13(8):10359-10367.

Chicago/Turabian Style

Chang, Te-Sheng; Chao, Shih-Yu; Ding, Hsiou-Yu. 2012. "Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan." Int. J. Mol. Sci. 13, no. 8: 10359-10367.

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