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Int. J. Mol. Sci. 2012, 13(8), 10359-10367; doi:10.3390/ijms130810359
Article

Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan

1,* , 1
 and
2,*
Received: 4 July 2012 / Revised: 8 August 2012 / Accepted: 9 August 2012 / Published: 20 August 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.
Keywords: Caesalpinia sappan; inhibition; melanogenesis; sappanone A; tyrosinase Caesalpinia sappan; inhibition; melanogenesis; sappanone A; tyrosinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chang, T.-S.; Chao, S.-Y.; Ding, H.-Y. Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan. Int. J. Mol. Sci. 2012, 13, 10359-10367.

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