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Int. J. Mol. Sci. 2012, 13(7), 8364-8378; doi:10.3390/ijms13078364

Risk-Association of DNA Methyltransferases Polymorphisms with Gastric Cancer in the Southern Chinese Population

1
School of Biotechnology, Southern Medical University, Guangzhou 510515, China
2
The First Clinical College, Southern Medical University, Guangzhou 510515, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 22 April 2012 / Revised: 20 June 2012 / Accepted: 27 June 2012 / Published: 5 July 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

DNA hypomethylation and/or hypermethylation are presumed to be early events in carcinogenesis, and one or more DNA methyltransferases (DNMTs) have been suggested to play roles in carcinogenesis of gastric cancer (GC). However, there have been no systematic studies regarding the association between DNMT gene polymorphisms and GC risk. Here, we examined the associations of 16 single nucleotide polymorphisms (SNPs) from DNMT1 (rs2114724, rs2228611, rs2228612, rs8101866, rs16999593), DNMT2 (rs11695471, rs11254413), DNMT3A (rs1550117, rs11887120, rs13420827, rs13428812, rs6733301), DNMT3B (rs2424908, rs2424913, rs6087990) and DNMT3L (rs113593938) with GC in the Southern Chinese population. We assessed the associations of these 16 SNPs with GC in a case-control study that consisted of 242 GC cases and 294 controls, using the Sequenom MALDI-TOF-MS platform. Association analyses based on the χ2 test and binary logistic regression were performed to determine the odds ratio (OR) and 95% confidence interval (95%CI) for each SNP. We found that rs16999593 in DNMT1, rs11254413 in DNMT2 and rs13420827 in DNMT3A were significantly associated with GC susceptibility (OR 1.45, 0.15, 0.66, respectively; 95% CI 1.00–2.11, p = 0.047; 0.08–0.27, p < 0.01; 0.45–0.97, p = 0.034, respectively, overdominant model). These results suggested that DNMT1, DNMT2 and DNMT3A may play important roles in GC carcinogenesis. However, further studies are required to elucidate the mechanism. View Full-Text
Keywords: gastric cancer (GC); DNMTs; single nucleotide polymorphism (SNP); susceptibility gastric cancer (GC); DNMTs; single nucleotide polymorphism (SNP); susceptibility
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yang, X.-X.; He, X.-Q.; Li, F.-X.; Wu, Y.-S.; Gao, Y.; Li, M. Risk-Association of DNA Methyltransferases Polymorphisms with Gastric Cancer in the Southern Chinese Population. Int. J. Mol. Sci. 2012, 13, 8364-8378.

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