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Int. J. Mol. Sci. 2012, 13(7), 7886-7901; doi:10.3390/ijms13077886

Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer

Department of Systems Medicine, University of “Tor Vergata”, Via Montpellier 1, Rome 00133, Italy
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Received: 1 June 2012 / Revised: 18 June 2012 / Accepted: 20 June 2012 / Published: 25 June 2012
(This article belongs to the collection Programmed Cell Death and Apoptosis)
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Abstract

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily, interacts with its functional death receptors (DRs) and induces apoptosis in a wide range of cancer cell types. Therefore, TRAIL has been considered as an attractive agent for cancer therapy. However, many cancers are resistant to TRAIL-based therapies mainly due to the reduced expression of DRs and/or up-regulation of TRAIL pathway-related anti-apoptotic proteins. Compounds that revert such defects restore the sensitivity of cancer cells to TRAIL, suggesting that combined therapies could help manage neoplastic patients. In this article, we will focus on the TRAIL-sensitizing effects of natural products and synthetic compounds in colorectal cancer (CRC) cells and discuss the molecular mechanisms by which such agents enhance the response of CRC cells to TRAIL.
Keywords: DR4; DR5; caspase-8; p53; CHOP; survivin; extrinsic pathway; intrinsic pathway; chemotherapeutics; natural products DR4; DR5; caspase-8; p53; CHOP; survivin; extrinsic pathway; intrinsic pathway; chemotherapeutics; natural products
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Stolfi, C.; Pallone, F.; Monteleone, G. Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer. Int. J. Mol. Sci. 2012, 13, 7886-7901.

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