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New Antifungal Pyranoisoflavone from Ficus tikoua Bur.
College of Plant Protection and Institute of Pesticide Science, Northwest A & F University, Yangling, Shaanxi 712100, China
* Author to whom correspondence should be addressed.
Received: 4 May 2012; in revised form: 5 June 2012 / Accepted: 7 June 2012 / Published: 14 June 2012
Abstract: Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2",2"-dimethylpyrano (5",6":7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and lupiwighteone (3) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR (1H-1H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MSn analyses. The antifungal activities of 1–3 against Phytophthora infestans were evaluated by direct spore germination assay, and the IC50 values were 262.442, 198.153 and 90.365 µg·mL−1, respectively.
Keywords: Ficus tikoua Bur.; pyranoisoflavone; antifungal activity
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MDPI and ACS Style
Wei, S.; Wu, W.; Ji, Z. New Antifungal Pyranoisoflavone from Ficus tikoua Bur.. Int. J. Mol. Sci. 2012, 13, 7375-7382.
Wei S, Wu W, Ji Z. New Antifungal Pyranoisoflavone from Ficus tikoua Bur.. International Journal of Molecular Sciences. 2012; 13(6):7375-7382.
Wei, Shaopeng; Wu, Wenjun; Ji, Zhiqin. 2012. "New Antifungal Pyranoisoflavone from Ficus tikoua Bur.." Int. J. Mol. Sci. 13, no. 6: 7375-7382.