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Int. J. Mol. Sci. 2012, 13(6), 7375-7382; doi:10.3390/ijms13067375

New Antifungal Pyranoisoflavone from Ficus tikoua Bur.

College of Plant Protection and Institute of Pesticide Science, Northwest A & F University, Yangling, Shaanxi 712100, China
* Author to whom correspondence should be addressed.
Received: 4 May 2012 / Revised: 5 June 2012 / Accepted: 7 June 2012 / Published: 14 June 2012
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Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2",2"-dimethylpyrano (5",6":7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and lupiwighteone (3) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR (1H-1H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MSn analyses. The antifungal activities of 13 against Phytophthora infestans were evaluated by direct spore germination assay, and the IC50 values were 262.442, 198.153 and 90.365 µg·mL−1, respectively.
Keywords: Ficus tikoua Bur.; pyranoisoflavone; antifungal activity Ficus tikoua Bur.; pyranoisoflavone; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Wei, S.; Wu, W.; Ji, Z. New Antifungal Pyranoisoflavone from Ficus tikoua Bur.. Int. J. Mol. Sci. 2012, 13, 7375-7382.

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