• Abstract
• Full-Text PDF [201 KB]
• Full-Text XML
• Article Versions Notes
• Supplement File 1

• Article Statistics
• PubMed/Medline
• Google Scholar
• Order Reprints

• Cite this article
• Export to BibTeX
• Export to EndNote

• [+] on DOAJ
• Wei, S
• Wu, W
• Ji, Z
• [+] on Google Scholar
• Wei, S
• Wu, W
• Ji, Z
• [+] on PubMed
• Wei, S
• Wu, W
• Ji, Z

•  CiteULike
•  Facebook
•  Mendeley
•  Twitter

This article is

• freely available
• re-usable

Int. J. Mol. Sci. 2012, 13(6), 7375-7382; doi:10.3390/ijms13067375

Article

New Antifungal Pyranoisoflavone from Ficus tikoua Bur.

Shaopeng Wei, Wenjun Wu and Zhiqin Ji*

College of Plant Protection and Institute of Pesticide Science, Northwest A & F University, Yangling, Shaanxi 712100, China

* Author to whom correspondence should be addressed.

Received: 4 May 2012; in revised form: 5 June 2012 / Accepted: 7 June 2012 / Published: 14 June 2012

Download PDF Full-Text [201 KB, uploaded 14 June 2012 11:51 CEST]

Abstract: Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2",2"-dimethylpyrano (5",6":7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and lupiwighteone (3) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR (¹H-¹H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MSⁿ analyses. The antifungal activities of 1–3 against Phytophthora infestans were evaluated by direct spore germination assay, and the IC₅₀ values were 262.442, 198.153 and 90.365 µg·mL⁻¹, respectively.

Keywords: Ficus tikoua Bur.; pyranoisoflavone; antifungal activity

Supplementary Files

• Supplementary File 1:

  PDF-Document (PDF, 1531 KB)

Article Statistics

Cite This Article