Next Article in Journal
Aroma Volatile Compounds from Two Fresh Pineapple Varieties in China
Previous Article in Journal
Role of Microglia in Oxidative Toxicity Associated with Encephalomycarditis Virus Infection in the Central Nervous System
Int. J. Mol. Sci. 2012, 13(6), 7375-7382; doi:10.3390/ijms13067375

New Antifungal Pyranoisoflavone from Ficus tikoua Bur.

College of Plant Protection and Institute of Pesticide Science, Northwest A & F University, Yangling, Shaanxi 712100, China
* Author to whom correspondence should be addressed.
Received: 4 May 2012 / Revised: 5 June 2012 / Accepted: 7 June 2012 / Published: 14 June 2012
View Full-Text   |   Download PDF [201 KB, uploaded 19 June 2014]   |  


Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2",2"-dimethylpyrano (5",6":7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and lupiwighteone (3) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR (1H-1H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MSn analyses. The antifungal activities of 13 against Phytophthora infestans were evaluated by direct spore germination assay, and the IC50 values were 262.442, 198.153 and 90.365 µg·mL−1, respectively.
Keywords: Ficus tikoua Bur.; pyranoisoflavone; antifungal activity Ficus tikoua Bur.; pyranoisoflavone; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material


Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Wei, S.; Wu, W.; Ji, Z. New Antifungal Pyranoisoflavone from Ficus tikoua Bur.. Int. J. Mol. Sci. 2012, 13, 7375-7382.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert