Next Article in Journal
Previous Article in Journal
Int. J. Mol. Sci. 2012, 13(6), 7365-7374; doi:10.3390/ijms13067365
Review

Role of Microglia in Oxidative Toxicity Associated with Encephalomycarditis Virus Infection in the Central Nervous System

1
, 2
 and 3,*
Received: 2 May 2012; in revised form: 28 May 2012 / Accepted: 5 June 2012 / Published: 14 June 2012
View Full-Text   |   Download PDF [172 KB, uploaded 19 June 2014]
Abstract: The single-stranded RNA encephalomyocarditis virus (EMCV) can replicate in the central nervous system (CNS) and lead to prominent brain lesions in the stratum pyramidale hippocampus and the stratum granulosum cerebelli. Activated microglia cells infected by EMCV produce a massive burst of reactive oxygen species (ROS) via NADPH oxidase 2 (NOX2) activation, leading to neuronal death. Balancing this effect is mechanisms by which ROS are eliminated from the CNS. Cellular prion protein (PrPC) plays an important antioxidant role and contributes to cellular defense against EMCV infection. This review introduces recent knowledge on brain injury induced by EMCV infection via ROS generation as well as the involvement of various mediators and regulators in the pathogenesis.
Keywords: encephalomyocarditis virus (EMCV); reactive oxygen species (ROS); NADPH oxidase (NOX); microglia encephalomyocarditis virus (EMCV); reactive oxygen species (ROS); NADPH oxidase (NOX); microglia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Ano, Y.; Sakudo, A.; Onodera, T. Role of Microglia in Oxidative Toxicity Associated with Encephalomycarditis Virus Infection in the Central Nervous System. Int. J. Mol. Sci. 2012, 13, 7365-7374.

AMA Style

Ano Y, Sakudo A, Onodera T. Role of Microglia in Oxidative Toxicity Associated with Encephalomycarditis Virus Infection in the Central Nervous System. International Journal of Molecular Sciences. 2012; 13(6):7365-7374.

Chicago/Turabian Style

Ano, Yasuhisa; Sakudo, Akikazu; Onodera, Takashi. 2012. "Role of Microglia in Oxidative Toxicity Associated with Encephalomycarditis Virus Infection in the Central Nervous System." Int. J. Mol. Sci. 13, no. 6: 7365-7374.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert