Next Article in Journal
Pokemon Silencing Leads to Bim-Mediated Anoikis of Human Hepatoma Cell QGY7703
Previous Article in Journal
Relationships Between Base-Catalyzed Hydrolysis Rates or Glutathione Reactivity for Acrylates and Methacrylates and Their NMR Spectra or Heat of Formation
Int. J. Mol. Sci. 2012, 13(5), 5801-5817; doi:10.3390/ijms13055801

In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms

1,2,* , 1
1 Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, China 2 Northeast Forestry University, 26 Hexing Road, Xiangfang District, Harbin 150040, China 3 Institut des Régions Arides de Médenine, Laboratoire d’Aridoculture et Cultures Oasiennes, Médenine 4119, Tunisia
* Author to whom correspondence should be addressed.
Received: 14 March 2012 / Revised: 28 April 2012 / Accepted: 7 May 2012 / Published: 15 May 2012
View Full-Text   |   Download PDF [280 KB, uploaded 19 June 2014]   |   Browse Figures


Polysaccharides were extracted from eight kinds of Chinese mushrooms using three solvents and were evaluated for their total carbohydrate, polyphenolic and protein contents, and antioxidant and anti-proliferation activities. The results suggested that all the polysaccharides had significant antioxidant capacities (EC50 ranged from 1.70 ± 0.42 to 65.98 ± 1.74 μM TE/g crude polysaccharide inhibition of ABTS+, EC50 ranged from 5.06 ± 0.12 to 127.38 ± 1.58 mg VCE/g CP scavenging of OH· and EC50 ranged from 0.70 ± 0.04 to 33.54 ± 0.49 mg VCE/g CP inhibition of lipid peroxidation) (TE: trolox equivalent; VCE: VC equivalent; CP: crude polysaccharide). The acid extracts of Russula vinosa Lindblad had the highest ABTS+ scavenging activity. Aqueous extracts of Dictyophora indusiata and Hohenbuehelia serotina possessed, respectively, the highest OH· scavenging capacity and ability to inhibit lipid peroxidation. Mushroom extracts also inhibited proliferation of HeLa and HepG2 cells in a dose-dependent manner. These results indicate that the mushroom polysaccharides might be potential antioxidant resources.
Keywords: mushrooms; polysaccharides; antioxidant; anti-proliferation mushrooms; polysaccharides; antioxidant; anti-proliferation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Li, X.; Wang, Z.; Wang, L.; Walid, E.; Zhang, H. In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms. Int. J. Mol. Sci. 2012, 13, 5801-5817.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert