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Int. J. Mol. Sci. 2012, 13(5), 5801-5817; doi:10.3390/ijms13055801

In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms

Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, China
Northeast Forestry University, 26 Hexing Road, Xiangfang District, Harbin 150040, China
Institut des Régions Arides de Médenine, Laboratoire d’Aridoculture et Cultures Oasiennes, Médenine 4119, Tunisia
Author to whom correspondence should be addressed.
Received: 14 March 2012 / Revised: 28 April 2012 / Accepted: 7 May 2012 / Published: 15 May 2012
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Polysaccharides were extracted from eight kinds of Chinese mushrooms using three solvents and were evaluated for their total carbohydrate, polyphenolic and protein contents, and antioxidant and anti-proliferation activities. The results suggested that all the polysaccharides had significant antioxidant capacities (EC50 ranged from 1.70 ± 0.42 to 65.98 ± 1.74 μM TE/g crude polysaccharide inhibition of ABTS+, EC50 ranged from 5.06 ± 0.12 to 127.38 ± 1.58 mg VCE/g CP scavenging of OH· and EC50 ranged from 0.70 ± 0.04 to 33.54 ± 0.49 mg VCE/g CP inhibition of lipid peroxidation) (TE: trolox equivalent; VCE: VC equivalent; CP: crude polysaccharide). The acid extracts of Russula vinosa Lindblad had the highest ABTS+ scavenging activity. Aqueous extracts of Dictyophora indusiata and Hohenbuehelia serotina possessed, respectively, the highest OH· scavenging capacity and ability to inhibit lipid peroxidation. Mushroom extracts also inhibited proliferation of HeLa and HepG2 cells in a dose-dependent manner. These results indicate that the mushroom polysaccharides might be potential antioxidant resources. View Full-Text
Keywords: mushrooms; polysaccharides; antioxidant; anti-proliferation mushrooms; polysaccharides; antioxidant; anti-proliferation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, X.; Wang, Z.; Wang, L.; Walid, E.; Zhang, H. In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms. Int. J. Mol. Sci. 2012, 13, 5801-5817.

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