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Int. J. Mol. Sci. 2012, 13(5), 5801-5817; doi:10.3390/ijms13055801
Article

In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms

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Received: 14 March 2012; in revised form: 28 April 2012 / Accepted: 7 May 2012 / Published: 15 May 2012
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Abstract: Polysaccharides were extracted from eight kinds of Chinese mushrooms using three solvents and were evaluated for their total carbohydrate, polyphenolic and protein contents, and antioxidant and anti-proliferation activities. The results suggested that all the polysaccharides had significant antioxidant capacities (EC50 ranged from 1.70 ± 0.42 to 65.98 ± 1.74 μM TE/g crude polysaccharide inhibition of ABTS+, EC50 ranged from 5.06 ± 0.12 to 127.38 ± 1.58 mg VCE/g CP scavenging of OH· and EC50 ranged from 0.70 ± 0.04 to 33.54 ± 0.49 mg VCE/g CP inhibition of lipid peroxidation) (TE: trolox equivalent; VCE: VC equivalent; CP: crude polysaccharide). The acid extracts of Russula vinosa Lindblad had the highest ABTS+ scavenging activity. Aqueous extracts of Dictyophora indusiata and Hohenbuehelia serotina possessed, respectively, the highest OH· scavenging capacity and ability to inhibit lipid peroxidation. Mushroom extracts also inhibited proliferation of HeLa and HepG2 cells in a dose-dependent manner. These results indicate that the mushroom polysaccharides might be potential antioxidant resources.
Keywords: mushrooms; polysaccharides; antioxidant; anti-proliferation mushrooms; polysaccharides; antioxidant; anti-proliferation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, X.; Wang, Z.; Wang, L.; Walid, E.; Zhang, H. In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms. Int. J. Mol. Sci. 2012, 13, 5801-5817.

AMA Style

Li X, Wang Z, Wang L, Walid E, Zhang H. In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms. International Journal of Molecular Sciences. 2012; 13(5):5801-5817.

Chicago/Turabian Style

Li, Xiaoyu; Wang, Zhenyu; Wang, Lu; Walid, Elfalleh; Zhang, Hua. 2012. "In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms." Int. J. Mol. Sci. 13, no. 5: 5801-5817.



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