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Int. J. Mol. Sci. 2012, 13(5), 5506-5518; doi:10.3390/ijms13055506

Article

Evaluation of Antioxidant and Antiproliferative Properties of Three Actinidia (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) Extracts in Vitro

Li-Li Zuo ¹ , Zhen-Yu Wang ^1,2,* , Zi-Luan Fan ¹ , Shuang-Qi Tian ¹  and Jia-Ren Liu ³

¹ School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China ² School of Forestry, Northeast Forestry University, 26 HeXing Road, DongLi District, Harbin 150040, China ³ Harvard Medical School, 300 Longwood Ave., Boston, MA 02115-5737, USA

* Author to whom correspondence should be addressed.

Received: 9 April 2012; in revised form: 27 April 2012 / Accepted: 3 May 2012 / Published: 8 May 2012

(This article belongs to the Section Bioactives and Nutraceuticals)

Download PDF Full-Text [449 KB, uploaded 8 May 2012 09:50 CEST]

Abstract: The total phenolic content, total flavonoid content, vitamin C content, and antioxidant activities of ethanol extracts from different kiwifruit varieties (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) were determined in this study. Multiple scavenging activity assays including the hydroxyl radical, O₂⁻·radical, DPPH, and the ABTS⁺ radical scavenging activity assays were used to identify the antioxidant activities of Actinidia extracts. The cell viability of HepG2 and HT-29 cells was also examined in this study. The results demonstrated that the Actinidia kolomikta extract had a higher antioxidant activity than the other two Actinidia extracts. There is a positive correlation between antioxidant activity and the polyphenols and vitamin C content in all three extracts (R² ≥ 0.712, p < 0.05). The Actinidia arguta extract had the highest inhibitory effect on HepG2 and HT-29 cell growth. These results provide new insight into the health functions of fruit and demonstrate that Actinidia extracts can potentially have health benefits.

Keywords: Actinidia, total phenolic content; flavonoids; antioxidant activity; antiproliferative activity

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