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Int. J. Mol. Sci. 2012, 13(5), 5506-5518; doi:10.3390/ijms13055506
Article

Evaluation of Antioxidant and Antiproliferative Properties of Three Actinidia (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) Extracts in Vitro

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Received: 9 April 2012; in revised form: 27 April 2012 / Accepted: 3 May 2012 / Published: 8 May 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The total phenolic content, total flavonoid content, vitamin C content, and antioxidant activities of ethanol extracts from different kiwifruit varieties (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) were determined in this study. Multiple scavenging activity assays including the hydroxyl radical, O2·radical, DPPH, and the ABTS+ radical scavenging activity assays were used to identify the antioxidant activities of Actinidia extracts. The cell viability of HepG2 and HT-29 cells was also examined in this study. The results demonstrated that the Actinidia kolomikta extract had a higher antioxidant activity than the other two Actinidia extracts. There is a positive correlation between antioxidant activity and the polyphenols and vitamin C content in all three extracts (R2 ≥ 0.712, p < 0.05). The Actinidia arguta extract had the highest inhibitory effect on HepG2 and HT-29 cell growth. These results provide new insight into the health functions of fruit and demonstrate that Actinidia extracts can potentially have health benefits.
Keywords: Actinidia, total phenolic content; flavonoids; antioxidant activity; antiproliferative activity Actinidia, total phenolic content; flavonoids; antioxidant activity; antiproliferative activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zuo, L.-L.; Wang, Z.-Y.; Fan, Z.-L.; Tian, S.-Q.; Liu, J.-R. Evaluation of Antioxidant and Antiproliferative Properties of Three Actinidia (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) Extracts in Vitro. Int. J. Mol. Sci. 2012, 13, 5506-5518.

AMA Style

Zuo L-L, Wang Z-Y, Fan Z-L, Tian S-Q, Liu J-R. Evaluation of Antioxidant and Antiproliferative Properties of Three Actinidia (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) Extracts in Vitro. International Journal of Molecular Sciences. 2012; 13(5):5506-5518.

Chicago/Turabian Style

Zuo, Li-Li; Wang, Zhen-Yu; Fan, Zi-Luan; Tian, Shuang-Qi; Liu, Jia-Ren. 2012. "Evaluation of Antioxidant and Antiproliferative Properties of Three Actinidia (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) Extracts in Vitro." Int. J. Mol. Sci. 13, no. 5: 5506-5518.



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